Publications by authors named "V A Molinari"
Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), H3 K27-altered, diffuse hemispheric glioma (DHG), H3 G34-mutant). The WHO classification recognises in exceptional cases, these mutations co-occur. We report one such case of a 2-year-old female presenting with neurological symptoms; MRI imaging identified a brainstem lesion which was biopsied.
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- The Manta Vascular Closure Device, designed for closing large-bore arterial accesses, was evaluated to see if it performs as well as the ProGlide device in terms of achieving hemostasis after endovascular procedures.
- A retrospective study was conducted on 524 cases of (T)EVAR procedures between January 2021 and April 2023, comparing outcomes of 355 procedures using Manta versus 169 using ProGlide.
- Results showed similar complication rates and effectiveness for both devices, although Manta had a statistically larger sheath size, indicating that both are viable options for vascular closure.
Article Synopsis
- Diffuse hemispheric gliomas, specifically H3G34R/V-mutant, are aggressive brain tumors with no current targeted therapies and come from neural precursor cells.
- Researchers found that these tumors display developmental patterns similar to healthy brain interneurons and identified key genes that these tumor cells depend on, especially CDK6.
- Targeting CDK6 with inhibitors showed promising results in reducing tumor growth and improving survival in experimental models, with one patient showing a significant response to treatment.
Guided by the Rowe and Kahn model, the current study examined the longitudinal association of objective and subjective components of successful aging (SA) with individuals' life satisfaction and level of optimism across adulthood aiming to validate the related scanty existing research. Data were from waves 2 and 3 (2004-14) of the Midlife in the United States (MIDUS) study. Using structural equation modeling, we examined ( = 2,040) whether subjective life satisfaction (wave 2) has any effect on a composite measure of SA (wave 3) while controlling for baseline sociodemographic and health factors.
View Article and Find Full Text PDFQuality of care in assisted living communities (ALCs) is important to consumers. The coronavirus disease of 2019 (COVID-19) pandemic and associated emergency policies have posed major challenges on staff recruitment and retention. This study aimed to examine the relationship between organizational characteristics of ALCs in Florida and challenges with staff absence during COVID-19 ( = 129 ALCs).
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