[PARTICIPATION OF NO-ERGIC MECHANISMS IN REALIZATION OF RESPIRATORY EFFECTS OF PRO-INFLAMMATORY CYTOKINE INTERLEUKIN-1-BETA].

The role of NO-ergic mechanisms in the realization of the respiratory effects of pro-inflammatory cytokine IL-1beta was investigated in acute experiments on anesthetized rats. To achieve this, we studied the effect of intravenous administration of IL-1beta during inhibition of NO-synthase by N-nitro-L-arginine methyl ester (L-NAME, a non-specific blocker of NO-synthase) on the parameters of breathing and the Hering-Breuer inspiratory-inhibitory reflex. It was shown that the effect of L-NAME eliminates the IL-1beta-dependent increase of the Hering-Breuer reflex, whereas effects on breathing pattern does not change: the increase in IL-1beta system-level evokes an increase in respiratory rate, tidal volume and lung ventilation.

[MECHANISMS OF MODULATION OF REFLEX CONTROL OF BREATHING AT ELEVATED SYSTEMIC LEVEL OF PROINFLAMMATORY CYTOKINE INTERLEUKIN-1β].

This study explores the hypothesis about the possible involvement of the cyclooxygenase pathway in the effects of interleukin-1beta (IL-1β) on the breathing pattern and Heuring-Breuer respiratory reflexes. Respiratory frequency (fR), tidal volume (VT) and esophageal pressure were recorded in 29 adult male Wistar rats anaesthetized with urethane. Heuring-Breuer reflexes were tested by airway occlusion at achieving functional residual capacity (inspiratory-inhibitory reflex), and at the height of inspiration (expiratory-promoting reflex).