Publications by authors named "V A McLin"
Adults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment. While the underlying cellular and molecular mechanisms are still incompletely understood, ammonium and bile acids (BAs) seem to play a key role in this pathology, by crossing the blood-brain-barrier and modifying neuronal homeostasis and synaptic plasticity. This experimental study aimed to investigate the effects of ammonium and BAs on dendritic spines of rat hippocampal CA1 neurons.
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- Paediatric acute liver failure is a serious condition that has high rates of illness and death, presenting challenges for medical professionals in its management.
- Emergency liver transplantation is necessary for 10-20% of patients, but about 10% are considered too unwell for the procedure due to medical or ethical reasons.
- The scarcity of donor livers necessitates a careful assessment of transplant eligibility, taking into account medical, social, logistical, and ethical factors to avoid unnecessary risks and ensure fair allocation of resources.
Background: Intestinal complications (IC) represent serious adverse events after liver transplantation (LT), however limited research has been conducted in pediatric cohorts. This study aims to describe IC after pediatric LT and to identify associated factors.
Methods: Retrospective review of 153 patients having undergone LT, aged 0-18 years, treated in the Swiss Pediatric Liver Center in Geneva.
Background: Prenatally diagnosed hepatic hilar cysts are a challenging finding for the clinician. They can either be a sign of cystic biliary atresia (BA) or a choledochal cyst (CC), two diagnoses with different postnatal management and prognosis. Based on a case report of four patients, we aim to propose a management algorithm for prenatally diagnosed "hepatic hilar cysts".
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- In 2022, the Biliary Atresia and Related Diseases (BARD) community developed a standardized definition for diagnosing cholangitis in biliary atresia (BA) patients, which was then assessed in a study involving data from 2010 to 2020 at two medical centers.
- The study found that out of 185 BA patients, 32% experienced at least one episode of cholangitis in the first year after surgery, and there was a strong correlation (0.8) between the new standardized definition and the doctors' clinical diagnoses.
- The results indicate that while the standardized definition coincided closely with clinicians' assessments, a prospective study is recommended to further refine this definition for better future diagnoses.