Deviations of patients with drug addiction value and meaning sphere functioning.

Objective: The aim of this article is to study empirically drug addicts value-meaning sphere disorders.

Patients And Methods: Materials and methods: To study the drug addicts value-meaning sphere disorders indicators, Schwarz's «Value Questionnaire» and a structured interview of the respondents, aimed at studying the specifics of their meaning constructs, was used.

Results: Results: Meaning structure disorders are analyzed on the basis of the constructs and images of fixed imagination, which are used by drug addicts to describe the role of the addictive agent in their life, description.

Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels.

We studied the effect of NO synthesis blockade on the hydrouretic function and the state of renal interstitial matrix in WAG rats with normal blood vasopressin level and Brattleboro rats lacking endogenous vasopressin. In WAG rats, impaired osmotic concentration accompanied by an increase in the content of histochemically detectable glycosaminoglycans in the inner medullary interstitium was observed under conditions of NO synthesis blockade. In Brattleboro rats, NO synthesis inhibition, on the contrary, induced an antidiuretic response without significant changes in the renal extracellular matrix.

Untargeted search and identification of metabolites of antiviral agent camphecene in rat urine by liquid chromatography and mass spectrometry and studying their distribution in organs following peroral administration of the compound.

Major metabolites of camphecene, a new effective antiviral agent, formed after its oral administration to rats and excreted in the urine, were found and identified using liquid chromatography coupled to mass spectrometry as well as multivariate analysis of HPLC-MS data. The metabolites were found to be camphecene glucuronide, camphecene sulfate and the corresponding iminoacid. A study of the dynamics of accumulation of camphecene and its metabolites in the liver, kidneys, lungs and brain of animals was performed.

Effect of New Antiviral Agent Camphecin on Behavior of Mice.

We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test.

APPLICATION OF APNEIC OXYGENATION IN TRACHEAL SURGERY.

Background: The tracheal surgery is associated with opening of airways and historically used different methods of maintaining gas exchange: System "shunt-breathing", the injection ventilation, high frequency jet ventilation and even artificial circulation. In recent years increased the interest of use of apneic oxygenation (A 0).

The Aim: to study the impact ofthe application ofA o on the gas exchange, acid-base balance of arterial blood, in patients undergoing reconstructive surgery on the trachea and bronchi with AO.