Publications by authors named "V A Kurilo"
We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.
View Article and Find Full Text PDFIntra-Arterial Stem Cell Transplantation in Experimental Stroke in Rats: Real-Time MR Visualization of Transplanted Cells Starting With Their First Pass Through the Brain With Regard to the Therapeutic Action.
Front Neurosci
March 2021
Article Synopsis
- - Cell therapy, particularly using directly reprogrammed neural precursor cells (drNPC), shows promise for reducing brain damage and improving recovery after a stroke, as tested in a rat model.
- - The study involved infusing drNPC into the bloodstream of rats 24 hours post-stroke, allowing tracking of these cells via MRI; results indicated that drNPC were present near and within the infarct zone more quickly than the control group of placenta-derived mesenchymal stem cells (pMSC).
- - Both drNPC and pMSC improved neurological function and reduced stroke effects, but they acted differently in terms of infarct volume and animal survival, hinting at unique therapeutic mechanisms at play, particularly for drNPC.
Impact of insect pests makes a significant limitation of the sugar beet crop yield. Integration of cry-genes of Bacillus thuringiensis into plant genome is one of the promising strategies to ensure plant resistance. The aim of this work was to obtain sugar beet lines (based on the MM 1/2 line) transformed with cry2A and cry1Cgenes.
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