[An analysis of the micronuclei in the oral mucosa of cancer patients for assessing the clastogenic effect of chemical preparations].

The frequency of micronuclei in the buccal mucosa cells have been investigated in healthy persons (donors) and patients with tumors before and after chemotherapy. It has been shown that frequency of micronuclei in the cells of patients before therapy and donors were at the same level. One day after chemotherapy the frequency of micronuclei was elevated 3.

[Relation of the antitumor activity of 4'-epidoxorubicin and cytogenetic disorders of tumor cells in experimental studies].

Antitumor and cytogenetic activities of 4-epi-doxorubicin (EDR), an anthracycline antibiotic, were studied on female Wistar rats with transplantable ascitic ovary tumor (OT). It was shown that after a single administration in a dose of 3 mg/kg, EDR prolonged the average lifespan of the tumor-bearing rats by 213.4 per cent as compared to that in the controls.

[Antimutagenic properties of sea buckthorn oil].

The influence of sea-buckthorn oil on cyclophosphamide, farmorubicin and dioxadet mutagenicity was studied. The oil decreased significantly the cytogenetic action of cyclophosphamide and farmorubicin, but not of dioxadet action. Possible mechanisms of antimutagenic action of the oil are discussed.

[The cytogenetic action of x-ray irradiation on the myelokaryocytes of rats immunized with a tularemia vaccine].

Immunization with tularemic live dry vaccine administered singularly to Wistar rats skin has been studied for its effect on mutagenicity induced after whole-body X irradiation. The analysis has shown that cytogenetic disturbance induced after X irradiation with doses of 0.5 Gy and 1.

[Decrease in the cytogenetic effect of adriblastin and pharmorubicin with the experimental use of tularemia vaccine].

Immunization of Wistar rats with tularemic vaccine has been studied for its influence on the cytogenetic effect of adryblastine and pharmorubicyn. It is shown that the number of aberrant metaphases considerably decreases in the myelocaryocytes of vaccinated rats. Antimutagenic effect is induced by the influence of tularemic vaccine on the metabolic activation processes of antibiotics and, possibly, by an increase of the activity of antioxidative enzymes in the rat organism.