A bank of protein family patterns for rapid identification of possible functions of amino acid sequences.

A method and software tool to develop patterns of protein families has been designed. These patterns are intended for the identification of local similarities in arbitrary amino acid sequences with proteins of the SWISS-PROT bank. The method is based on the physical, chemical and structural properties of amino acids.

[A bank of protein family images Prof-Image for rapid determination of possible functions of random amino acid sequences].

A bank of images of protein families (PROF IMAGE bank) is developed using early published method and amino acid sequences of 24-th release SWISS-PROT bank (27752 sequences). The method relies on physical-chemical and structural properties of amino acids and on the choice of fragments of protein families for the most discriminate distinction of amino acid sequences of a family from representatives of other families or random sequences. Specifications of the algorithms of building the images, principles of amino acid sequences selection to form protein families, the structure of the bank, and characteristics of images of 163 protein families are described.

A computer system for analysis and integrated description of regulation of the molecular-genetic system of interferon induction and action.

A new theoretical approach to elaboration of an information-analytical integrated knowledge base containing data on regulation and function of biological systems is presented. The knowledge base incorporates: (i) a reference database containing experimental data on the structural-functional organization of a biological system; (ii) a dynamic mathematical model for analysis of the evolution of the system over time; and (iii) an interpretation module of simulation results. Application of this approach to theoretical investigation of the interferon system in the case of viral infection is discussed.