Laboratory control of the osteoresorptive effects of glucorcorticoids in patients with purpose colitis.

The aim of the work was to develop an informative method for laboratory monitoring of osteoresorbent action during systemic administration of glucocorticoids in patients with ulcerative colitis. The study included 54 patients with ulcerative colitis aged 18 to 44 years: 35 (64,8%) men and 19 (35,2%) women. In patients of the clinical group before and after the first, second, third courses of glucocorticosteroids, as well as during the formation of steroid dependence, the concentration of the osteoresorption marker cathepsin K was determined simultaneously in the blood serum and gingival fluid by enzyme immunoassay.

[Combat-related posttraumatic stress disorder: from «irritable heart syndrome» to «psycho-organic disorder». Contemporary approach].

The authors consider current views on and approaches to trauma and posttraumatic stress disorder (PTSD). There are doubts about the correctness and validity of allocation of PTSD entirely according to psychogenesis of the disease. The authors consider the «post-traumatic» as a type of response to extreme stress.

[Combat-related posttraumatic stress disorder: the historical evolution of concept from 'irritable heart syndrome' to 'psycho-organic disorder'].

Nowadays PTSD is the most urgent problem in the field of world psychiatry due to its academic, practical, epidemiological significance and other aspects. The authors present a historical review of different conteptions explaining the development of posttraumatic stress disorder. Attention is drawn to the description of evolution of PTSD from psychogenic to complex forms, with the formation of bio-psycho-social approach to the problem.

[Neurotic disorders as a problem of modern gerontopsihiatry].

The relevance of the problem is determined by the growth of elderly population in the world and in Russia and by the increase in the frequency of non-psychotic mental disorders (non-PMD) in the structure of psychiatric diseases. The authors consider the current state of research in the field of non-PMD of old age, including neurotic disorders (ND). An analysis of the literature has shown that there is no convergent view on the ND of old age.