Tumor-Infiltrating Lymphocytes in Breast Cancer. Association with Clinical and Pathological Parameters.

In patients with primary resectable breast cancer, a positive correlation between the age and the count of CD16 lymphocytes and a negative correlation of this parameter with the number of regulatory CD4CD25CD127 cells and proliferative activity of Ki-67 tumor cells were revealed. Higher level of Ki-67 was associated with reduced number of effector lymphocytes (CD8 and CD16) and elevated content of regulatory CD8CD11bCD28 T cells. The absence of expression of estrogen receptors was associated with reduced cytotoxic potential of CD8 T cell in comparison with ER breast cancer.

miRNA and tropism of human parvovirus B19.

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2.

CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer.

Overexpression of CD24 is an independent prognostic factor for breast cancer. Recently, two polymorphisms in the CD24 gene were linked to disease risk and progression in autoimmune diseases. Here, we evaluated the clinical relevance of these polymorphisms with respect to their potential to predict a pathologic complete response (pCR) to neoadjuvant chemotherapy (NCT) for primary breast cancer (PBC), one of the strongest prognostic factors in this setting.

[Variations of the length of exons and introns in human genome genes].

The exon-intron organization of genes of all human chromosomes was studied in relation to the density of gene distribution on DNA strands and on the number of introns in genes. The lengths of exons, introns and genes have been found to vary correlatively, and this correlation depends on the density of genes in human chromosomes. It has been established that genes with the exon-intron organization have similar tendencies of variation of the lengths of exons and introns with an increase in the number of introns.

[Changes of introns and exons length in genes of arabidopsis, rice, nematode and human].

Genes of Arabidopsis thaliana, Orysa sativa, Caenorhabditis elegans, Homo sapiens have been studied by computer analysis. The average intron and exon lengths in genes of these organisms decreases with increase of intron number in genes. The length of introns and exons in A.