Publications by authors named "V A Kashuro"
Article Synopsis
- All living organisms possess biological clocks that regulate circadian rhythms, influencing various bodily functions like metabolism and hormone levels, and the gut microbiota plays a crucial role in health and stress response.
- A study involving male rats revealed that the intake of Lactobacillus brevis 47f improved cellular health and redox balance after exposure to different light cycles, demonstrating its potential to restore depleted cellular components.
- The administration of L. brevis 47f positively impacted the gut microbiota by increasing beneficial bacteria (Faecalibacterium and Roseburia) and decreasing potentially harmful ones (Prevotella and Bacteroides), highlighting its role in maintaining gut health.
Ten biochemical parameters total protein, albumin, glucose, cholesterol, urea, creatinine, total bilirubin, ALT, AST, APh were determined during long-term light mode changes in serum of rats. Changing the light mode, a number of parameters revealed unreliable 24-hour rhythms. An ultradian 12-hour reliable rhythm has been for serum total protein of rats exposed to constant darkness during 1 month.
View Article and Find Full Text PDFThis article describes models for the study of acute desynchronosis: jetlag syndrome and acute desynchronosis under physical stress for possible pharmacological correction of these disorders. The cosinor analysis allowed assessing significance of changes in biological rhythms in 2 biological models: the jetlag-type diurnal rhythm shift model and the model with changed light mode. The revealed changes in the rhythms of biochemical parameters in the blood serum of animals with acute desynchronosis indicate significant changes in the intensity of carbohydrate-lipid metabolism, which affected the processes of cell bioenergetics.
View Article and Find Full Text PDFSince the discovery in 2001, the G protein-coupled trace amine-associated receptor 1 (TAAR1) has become an important focus of research targeted on evaluation of its role in the central nervous system (CNS). Meanwhile, impact of TAAR1 in the peripheral organs is less investigated. Expression of TAAR1 was demonstrated in different peripheral tissues: pancreatic β-cells, stomach, intestines, white blood cells (WBC), and thyroid.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated how different lighting conditions (normal cycles, darkness, and constant light) affect the physiological health and gut microbiota of rats, revealing that changes in light can disrupt the body's internal clock and overall balance.
- - After monitoring various physiological markers over three months, results showed that constant light conditions led to significant hormonal and metabolic changes in the rats, indicating a breakdown in their internal synchronization.
- - The findings suggest that while the gut microbiota's composition changed in response to lighting conditions, its overall functional activity remained relatively stable, indicating that these changes may be the organism's way of compensating for new environmental conditions.