[Light pollution, desynchronosis and aging: the state of problem and solutions].

The effect of different light conditions (constant illumination, light deprivation, the standard regime of lighting and natural for Northwest Russia lighting in different seasons of the annual cycle) on indicators of biological age and homeostasis, the development of age-related pathology, oncogenesis and longevity of rats was investigated. Exposure to constant light on the studied parameters was evaluated at different ages--antenatal, early and late postnatal period. The data about influences of substances and hormones of pineal gland on biomarkers of aging, homeostasis, spontaneous oncogenesis and longevity in experimental animals was obtained.

[The influence of constant lightening on physiological parameters of rats homeostasis depending on time beginning of exposure].

The influence of constant lightening on biomarkers of ageing and rates of male rats aging was studied. It was revealed that the maintenance of rats in the constant lightening regime starting from the age of one month results in accelerated ageing of the organism, the reduction of the phases progressive and stable growth, early occurrence of presenile and senile periods, to the earlier occurrence of water-and-salt metabolism imbalance, accelerate the process of "aging" of the antioxidant system in comparison with the rates of the control group. On the contrary, the maintenance of rats in the constant lightening regime starting from the age of fourteen months slows ageing of the organism, increases body growth, delays appearance of pathological changes in the urine, slows down the "aging" of the enzymatic components of the antioxidant system.

[The melatonin influences on neutrophils/lymphocytes ratio of mammals blood depends on age of animals].

The influence of melatonin on age dynamics of neutrophils and lymphocytes in blood of laboratory rats kept under different light conditions and predatory mammals--farmer silver fox, raccoon dog kept under natural light (NL) was investigated. The decrease of lymphocyte level, increase neutrophils content and alteration of neutrophils/lymphocytes ratio of aged rats (24 months) kept under natural light (NL) and standard light (LD) and adult silver foxes (2-5 years) kept under natural light in comparison with juvenile animals were detected. The reduced lymphocytes level and increased neutrophil level in rats under constant light (LL) were revealed in younger ages.

[Influence of prenatal and postnatal illumination on male rat physiologycal parameters].

Influence of different light conditions on some physiological parameters of 3-month old male rats was studied. It was established that influence of constant light on mothers during pregnancy or on their posterity from birth leads to one-way changes of the antioxidant system, isoenzymatic spectrum of lactate dehydrogenase, blood indices and leucogram. However, the reaction is different and depends on moment of exposure.

[Effect of mutations affecting coat color on the blood lymphocyte structure in the American mink (Mustela vison Schreber, 1777)].

American minks with different genotypes containing the Aleutian coat color allele in the homozygous state, including the single recessive Aleutian (a/a); double recessive sapphire (a/a p/p) and lavender (m/m a/a); triple recessive violet (m/m a/a p/p); and dominant-recessive cross sapphire (S/+ a/a p/p), sapphire leopard (S(K)/+ a/a p/p), and shadow sapphire (S(H)/+ a/a p/p) minks, as well as American minks without the Aleutian allele, including the standard (+/+); single recessive silver-blue (p/p) and hedlund-white (h/h); double recessive pearl (k/k p/p), Finnish topaz (t(S)/t(S) b/b); incompletely dominant royal silver (S(R)/+), standard leopard (S(K)/+), and black crystal (C(R)/+); and dominant-recessive snowy topaz (C(R)/+ t(S)/t(S) b/b) and Kujtezhy-spotted (S(K)/+ b/b) minks have been studied. Homozygosity for the a allele has been found to disturb the subcellular structure of leukocyte, namely the formation of abnormally large granules.