Antioxidants selenomethionine and D-pantethine decrease the negative side effects of doxorubicin in NL/Ly lymphoma-bearing mice.

Aim: To investigate the potential tissue-protective effects of antioxidants selenomethionine and D-pantethine applied together with doxorubicin (Dx) on NK/Ly lymphoma-bearing mice. The impact of this chemotherapy scheme on animal survival, blood cell profile, hepatotoxicity, glutathione level, and activity of glutathione-converting enzymes in the liver was compared with the action of Dx applied alone..

Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study.

Aim: To use the antioxidant compounds (sodium selenite, selenomethionine, D-pantethine) for modulation of cytotoxic effect of doxorubicin and cisplatin toward wild type and drug-resistant mutants of several human tumor cells. Similar treatments were applied in vivo toward adult male Wistar rats.

Methods: Human tumor cells of different lines (HCT-116, Jurkat and HL-60) with various mechanisms of drug-resistance were treated with doxorubicin or cisplatin, alone or in combination with sodium selenite, selenomethionine, or D-pantethine.

[Biochemical basis of valproic acid toxicity: role of oxidative stress and effects of L-carnitine].

Reduced hepatic mitochondrial beta-oxidation and changes in L-carnitine metabolism are important biochemical manifestations of valproate (VA)-induced hepatic toxicity. Lipid peroxidation activation as a possible mechanism implicated in VA-induced damage as well as the possibility of L-carnitine (LC) attenuation of lipid peroxidation activity were studied. The level of malondialdehyde (MDA), lipid peroxide concentration and antioxidant activity (AOA), catalase activity, free S-S groups content in plasma and liver homogenates from male albino rats supplemented with VA (200 mg/kg, 8 days) and VA plus LC (100 mg/kg, 8 days) were measured.

[Coenzyme A biosynthesis as universal mechanism of conjugation of exogenous and multiple pantothenic acid functions].

Development of Academician R. V. Chagovets' ideas of the regulatory role of vitamins and their derivatives in thiol-containing compound metabolism and antioxidant system formation as well as in studying non-coenzymatic functions of B-vitamins and vitamin-binding proteins had a considerable effect on the almost 40-year studies on pantothenic acid metabolism and biochemical functions by scholars at the vitaminologic school in Grodno.

[Aggravation by halomethanes of damages in isolated erythrocyte membranes photosensitized by porphyrins].

It was found that halogen methanes (CCl4, CHBr3) enhance the destruction of protein tryptophanyls and lipid peroxidation photosensitized by Zn-tetraphenylporphin and Zn-tetramethylpyridylporphyrin in isolated erythrocyte membranes. It was shown that this effect is due to photoinduced electron transport from Zn-porphyrins to halogen methanes with the formation of highly reactive halogenmethyl radicals. The hydrophilic Zn-tetramethylpyridylporphyrin is more active at the photosensition of damage to membrane proteins, whereas the hydrophobic Zn-tetraphenylporphin is more effective in lipid peroxidation.