Effect of lornoxicam therapy on expression of TLR2 and TLR4 mRNA during systemic complications of acute pancreatitis.

Primary pancreatic injury that occurs in acute pancreatitis leads to necrosis of pancreatic cells and is accompanied by the development systemic inflammatory response of varying severity. Systemic inflammatory response, in turn, can lead to the development of multiple organ dysfunction syndrome and death of patients. The release of damage-associated molecular patterns into the extracellular space is the trigger pathological mechanism underlying these processes.

[The use of fibrin-collagen substance in case of spleen injuries].

Spleen damage is one of the most common injuries of the abdomen. Thus, splenectomy is one of the most common embodiments of the surgical procedure. Justified by the desire of surgeons to perform organ save surgery, which was made possible by the emergence of new hemostatic agents.

[Application of a glue substance in operations on the colon].

The incompetent intestinal suture in the colon is one of the most frequent complications in emergency surgery. A great number of studies have found that the main way to improve the immediate postoperative result is to create optimal conditions for healing the intestinal wall. The results of clinical and experimental research of the drug "Tachocomb" for strengthening the intestinal anastomosis are described.

[The systemic inflammatory response syndrome correction in acute destructive pancreatitis].

Acute pancreatitis is a disease of variable severity. In which some patients experience mild, self-limited attacks while others manifest a severe, highly morbid, and frequently lethal attack. The exact mechanisms by which diverse etiological factors induce an attack are still unclear.