Insulin resistance and hyperandrogenism drive steatosis and fibrosis risk in young females with PCOS.

Background And Aims: Nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) recognize obesity and insulin resistance (IR) as common pathogenic background. We assessed 1) whether PCOS is a risk factor for steatosis, and 2) the impact, in PCOS patients, of IR and hyperandrogenism on steatosis and fibrosis.

Methods: We considered 202 consecutive Italian PCOS nondiabetic patients and 101 age-matched controls.