A peptide-based hydrogel sequence was computationally predicted from the Ala-rich cross-linked domains of elastin. Three candidate peptides were subsequently synthesised and characterised as potential drug delivery vehicles. The elastin-derived peptides are Fmoc-FFAAAAKAA-NH, Fmoc-FFAAAKAA-NH, and Fmoc-FFAAAKAAA-NH.
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December 2022
Following the successful introduction of two benign solvents for cleaving protected acid peptide fragments from 2-chlorotrityl chloride (2-CTC) resin, there is a need to green the cleavage process for obtaining protected peptide amide fragments. In this work, p-xylene and toluene are introduced as greener alternates to dichloromethane (DCM) for preparing protected peptide amide fragments from a Sieber amide resin. The N-dealkylation is a demanding chemical reaction, requiring that the cleavage protocol be optimised to ensure complete cleavage from the resin.
View Article and Find Full Text PDFThe results of the precise measurement of the refractive index of stable germanium isotopes Ge72, Ge73, Ge74, and Ge76 single crystals with high enrichment and a germanium single-crystal Genat of natural isotopic composition with the Fourier-transform interference refractometry method from 1.94 to 20 μm with 0.1 cm resolution and accuracy of 2×10 to 1×10 are shown.
View Article and Find Full Text PDFA bulk nanostructured material based on oxidized silicon nanopowder was fabricated using a spark plasma sintering technique. Structural investigations revealed that this material has the composition of ∼14 nm core Si granules inside an SiO shell. Photoluminescence measurements have shown that the emission spectra lie in the energy range of 0.
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