Publications by authors named "V A Galenok"
In human milk we previously found catalytic antibodies (abzymes) catalyzing hydrolysis of DNA, RNA, NMP, NDP, and NTP and also phosphorylation of proteins and lipids. In the present study we have analyzed nuclease activities of antibodies in blood of women during pregnancy and lactation. Blood of healthy male and female volunteers lacked catalytically active antibodies, whereas antibodies from blood of pregnant women hydrolyzed DNA and RNA and their relative activity varied over a wide range.
View Article and Find Full Text PDFAim: To study clinico-immunological characteristics of diabetes mellitus type I.
Material And Methods: Clinical examination was made of 333 patients with diabetes mellitus type I with manifestation of carbohydrate metabolism impairment and intoxication syndrome because of diabetic ketoacidosis (group 1) and without it (group 2). Compared to donors (n = 68), T-cell, B-cell and monocytic components of immune system were studied in patients with uncomplicated DM type 1 in both groups (28 and 15 patients, respectively).
Aim: To clarify informative value of secretory ability of pancreatic beta-cells and correspondence of insulin values to glycemia in the course of standard glucose tolerance test (GTT) in detection of insulin-resistance in patients with arterial hypertension (AH) to verify metabolic syndrome (MS).
Material And Methods: Correlation and factor analyses were performed of correlations between glycemia, immunoreactive insulin (IRI), C-peptide, glucose/IRI in the course of GTT in 111 AH patients divided into groups by the sum of metabolic disturbances.
Results: The greatest number of correlations were seen for glucose/IRI fasting index.
Aim: To determine the role of estimated value HLA-DR+/CD19+ in patients with insulin-dependent diabetes mellitus (IDDM) in the course of the disease.
Materials And Methods: The number of CD+ and HLA-DR+ lymphocytes and the ratio HLA-DR+/ CD19+ were estimated in the peripheral blood of 70 IDDM patients aged 9-47 years with the disease duration since the diagnosis 0-10. Indirect immunofluorescence with monoclonal antibodies was employed.
Aim: The study of activity of T-effector lymphocytes of delayed-type hypersensitivity (DTH) in insulin-dependent diabetes (IDD) and effects of short-action insulins produced by different pharmaceutical firms.
Materials And Methods: 79 IDD patients aged 3-48 entered the study.
Results: T-effector lymphocytes activity in DTH patients was abnormal: leukocytes migration was enhanced due to inhibited production of the inhibiting factor.