[Apoptotic endonuclease EndoG induces alternative splicing of telomerase catalytic subunit hTERT and death of tumor cells].

Telomerase activity is known to be regulated by alternative splicing of its catalytic subunit hTERT (human Telomerase Reverse Transcriptase) mRNA. Induction of non-active spliced hTERT leads to inhibition of telomerase activity. However, very little is known about the mechanism of hTERT mRNA alternative splicing.

[The influence of compound aITEL1296 on telomerase activity and the growth of cancer cells].

Telomerase is a ribonucleoprotein that synthesizes telomeric repeats and identified as a promising target for anticancer therapy. Here we describe a new compound aITEL1296 as a potent telomerase inhibitor. Its inhibitory activity was a bit higher (IC50 = 0,19 +/- 0,02 ng/ml) than that of BIBR1532, one of the most potent telomerase inhibitors known to date.

[Influence of natural complex compounds with hipolipidemic activity on expression of bacteria virulence factors].

Natural complex compounds with hipolipidemic activity, having considerable inhibitory effect on expression of bacteria virulence factors were isolated. Inhibitory properties of the compounds with respect to pyocyanine and protease formation, as well as their influence on the quorum sensing mechanism in Chromobacterium violacium were shown.

[Effect of several compounds on the process of reduction of the 20-keto group of corticosteroids by a culture of Mycobacterium globiforme].

The effect of certain metabolites produced in the metabolism of carbohydrates, proteins and fats on the reduction of the 20-keto group in a number of corticosteroids (prednisone, prenisolone, 6 alpha-methylprednisolone) was studied with the culture of Mycobacterium globiforme. The metabolites and inhibitors of the respiration chain were found to stimulate the 20 beta-reduction of a steroid molecule. The inhibitor of oxidative phosphorylation, 2,4-dinitrophenol, inhibited the reduction of the 20-keto group in a steroid.

[Regulation of 1-dehydrogenation and 20 beta-reduction of ketosteroids by microorganisms].

Regulation of two microbiological processes--1-dehydrogenation and 20 beta-reduction of ketosteroids--was studied using several exogeneous quinones which (a) stimulated 1-dehydrogenation and (b) inhibited the accompanying reaction, the reduction of 20-ketogroup of the steroid molecule. The least active compounds were benzoquinones. The best regulators are 1,4-naphthoquinone, 1,2-naphthoquinone, and 7-methoxy-1,2-naphthoquinone.