[Carotenoids. Biological activities].

The review provides data on the biological activities of the most prevalent carotenoids. Special attention is paid to theirs anticancer and antiatherogenic properties, immunomodulating action, cardioprotective, radioprotective and photoprotective effects.

[The utilization of omegalicin in treatment of psoriasis].

The correcting action of omegalicin against the background of conventional treatment of psoriasis was investigated. It is established that omegalicin moderately increases the generation of active forms of oxygen needed to suppress the processes of proliferation at the expense of changing the activity of catalase, superoxide dismutase and glutathione peroxidase.

Role of 4-hydroxy-trans-2-nonenal in cell functions.

The role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis.

[Carotenoids. Bioavailability, biotransformation, antioxidant properties].

The review provides data on the structure and the major biotransformation pathways of the most prevalent carotenoids. Eventual mechanisms of their antiradical and antioxidant activity in different model systems in vitro are thoroughly discussed. Special attention is paid to carotenoids as potential membrane protector.

[Biologically active substances from medicinal plants as a factor of the organism detoxication].

Reported detail analysis of reguirements to the multicomponents plant systems for detoxication and cleaning of stomach and intestinal tract including absorption of harmful compounds, compensation of losses of benefit micronutrients, antiinflamatory, antiucler, anticancer activity, increase local immunity, activation of intestinal endocrinocytes, antioxidative and antihypoxantive activity ets. Molecular mechanisms of body detoxication with participation of medicinal and food plants compounds are discussed. Its include influence of this compounds on a) biochemical mechanism of detoxication and elimination from tissues of hydrophobic xenobiotics, drugs and hydrophobic metabolits (microsomal monooxygenases--cytochrome P-450--dependent system) and enzymes of conjugation(glutathion--S-transferase, glucuronyltransferase etc.