Publications by authors named "V A D Baettig"
Dynamics of antibody titers to SARS-CoV-2 and clinical outcomes after sotrovimab pre-exposure prophylaxis early after allogeneic hematopoietic stem cell transplantation.
Bone Marrow Transplant
May 2023
Article Synopsis
- The study examined infections in COVID-19 pneumonia patients, finding that secondary infections are important complications.
- Out of 162 hospitalized SARS-CoV-2-positive patients, a significant portion required intensive care, with a high incidence of bacterial and fungal infections among ICU patients.
- Overall, community-acquired infections were uncommon, while hospital-acquired infections were prevalent, especially in those needing intensive treatment.
Article Synopsis
- COVID-19 triggers inflammatory cytokine release, which reduces the effectiveness of drug metabolizing enzymes and alters drug levels in the bloodstream.
- A study of 92 hospitalized patients showed a significant correlation between plasma concentrations of lopinavir (LPV) and C-reactive protein (CRP), indicating that inflammation impacts LPV metabolism, while hydroxychloroquine (HCQ) concentrations did not correlate with CRP.
- Despite high LPV levels in COVID-19 patients, the concentrations were found to be insufficient in the lungs for effective treatment, suggesting that inflammation can inhibit important drug metabolism pathways.
[A Holiday Souvenir with Consequences - an Interdisciplinary Challenge].
Praxis (Bern 1994)
February 2020
A Holiday Souvenir with Consequences - an Interdisciplinary Challenge We describe a patient with a diabetic foot and challenging infectious complications. After a hospital stay in Sri Lanka due to a soft tissue infection of the foot he was relocated to Switzerland. After proof of multiple resistant bacteria, an amputation of the forefoot with a split skin cover was performed, followed by a short resistance-adapted antibiotic treatment, with good clinical results.
View Article and Find Full Text PDFContemporary, comprehensive data on epidemiology and outcomes of invasive fungal disease (IFD) including breakthrough IFD among allogeneic hematopoietic stem cell transplantation (HSCT) recipients are scarce. We included 479 allogeneic HSCT recipients with 10 invasive candidiasis (IC) and 31 probable/proven invasive mold disease (IMD) from the Swiss Transplant Cohort Study from 01.2009 to 08.
View Article and Find Full Text PDF