Preclinical Evaluation of Soluble Epoxide Hydrolase Inhibitor AMHDU against Neuropathic Pain.

Inhibition of soluble epoxide hydrolase (sEH) is a promising therapeutic strategy for treating neuropathic pain. These inhibitors effectively reduce diabetic neuropathic pain and inflammation induced by Freund's adjuvant which makes them a suitable alternative to traditional opioids. This study showcased the notable analgesic effects of compound (1,1'-(hexane-1,6-diyl)bis(3-((adamantan-1-yl)methyl)urea)) in both inflammatory and diabetic neuropathy models.

Elastomeric Fire and Heat-Protective Materials Containing Functionally Active Microheterogeneous Systems.

This research aims to explore how functionally active structures affect the physical, mechanical, thermal, and fire-resistant properties of elastomeric compositions using ethylene-propylene-diene rubber as a base. The inclusion of aluminosilicate microspheres, microfibers, and a phosphorus-boron-nitrogen-organic modifier in these structures creates a synergistic effect, enhancing the material's heat-insulating properties by strengthening coke and carbonization processes. This results in a 12-19% increase in heating time for unheated sample surfaces and a 6-17% increase in residual coke compared to existing analogs.

Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy.

Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measured IC values for some molecules were below the accuracy limit of the existing assays.

Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors.

A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.

Functionally Active Microheterogeneous Systems for Elastomer Fire- and Heat-Protective Materials.

Elastomeric materials are utilized for the short-term protection of products and structures operating under extreme conditions in the aerospace, marine, and oil and gas industries. This research aims to study the influence of functionally active structures on the physical, mechanical, thermophysical, and fire- and heat-protective characteristics of elastomer compositions. The physical and mechanical properties of elastomer samples were determined using Shimazu AG-Xplus, while morphological research into microheterogeneous systems and coke structures was carried out on a scanning electronic microscope, Versa 3D.