[Selection criteria for parameters of electric current in trans-CSF brain stimulation in patients with posttraumatic vegetative state].

Trans-CSF brain stimulation is on of applied methods of stimulation in posttraumatic vegetative state. The paper analyzes application of this technique under the control by different methods of electrophysiological monitoring. Authors suggest principles of selection of stimulation parameters and detectable criteria of its effectiveness.

[Treatment outcome of chemotherapy with superselective cerebral artery catheterization in vegetative state patients].

The purpose of the study is to assess the impact of superselective neurotransmitter metabolic therapy in patients in a vegetative state. Superselective intraarterial infusion was conducted on 26 patients with relevant international criteria for the diagnosis of vegetative state. Comprehensive assessment of neurologic symptoms and severity of low metabolism on PET scan allowed to select the vascular pool, for the catheter installation.

[Peculiarities of disorders of brain bioelectrical activity spatial-time organization in patients with different consciousness depression after severe head injury].

Specific changes of bioelectrical brain activity was found in 27 patients with different level of posttraumatic consciousness depression by the methods of crosscorrelation, coherence and factor analysis of EEG. The changes of activity of morphofunctional systems of intracerebral integrations were revealed partially by decreasing of unspecific activity from brainstem structures reflected with increasing of slow wave activity and decreasing of EEG coherence in alpha- and beta-range. Depression of system organization of interconnections of bioelectrical brain activity in frontal and occipital regions of both hemispheres was also detected, and testified about decreasing of intercortical and thalamocortical brain system action under brain dislocation.

[The role of rivastigmine (exelon) in the treatment of consequences of cranial-brain trauma].

The use of rivastigmine in the rehabilitation of patients with cognitive disturbances after cranial-brain trauma (CBT) is reviewed. Replacement of cholinergic deficit exerts a positive effect on sanogenetic process in the brain, facilitate consolidation and learning of afferent information in the restoring brain. The authors emphasize that the administration of neuromediator preparations needs the level of organization of integrative brain activity which is sufficient for the formation of awakening reaction (opening of eyes - awakening from coma).

[Effect of long-term microgravity on the vestibular function].

Comprehensive computerized oculomotor testing was used to investigate the vestibular function in 9 Russian members of ISS crews 3-9 on days 1 (2), 4 (5) and 8 (9) of return from long-term stay in microgravity (126 to 195 days). The vestibular function was assessed by the static otolith-cervical-ocular reflex, dynamic otolith-cervical-ocular reactions, vestibular reactivity, and spontaneous oculomotor activity. The postflight investigations revealed functional disorders in the peripheral (an increased vestibular reactivity, absent or damped otolith-cervical-ocular reflex), and central (spontaneous typical and atypical nystagmus, gaze nystagmus) vestibular analyzer.