Characterization of Forced Degradation Products of Netarsudil: Optimization and Validation of a Stability-Indicating RP-HPLC Method for Simultaneous Quantification of Process-Related Impurities.

Objectives: The aim of this study is to examine resolution, identification, and characterization of forced degradation products of netarsudil by liquid chromatography-tandem mass spectrometry by validating a simple and sensitive high-performance liquid chromatography method for the resolution, identification, and quantification of two process-related impurities in netarsudil.

Materials And Methods: Chromatographic separation was accomplished on a ZORBAX Eclipse XDB C18 (250 x 4.6 mm; 5 µ id) column at room temperature as the stationary phase and 257 nm as the detector wavelength with the mobile phase consisting of acetonitrile, methanol, and pH 4.

Data on road traffic incidents for Sydney greater metropolitan area.

A road network aims to facilitate the movement of commuters and goods in a safe, economical, and efficient way that contributes to growth in the economy. Road traffic incidents (RTIs), such as crashes, vehicle breakdowns, hazards, etc., are unexpected events that cause severe traffic congestion, unreliability, and pollution.

Determinants of speed variability on the horizontal curves of two-lane undivided rural highways passing through mountainous terrain.

Drivers traversing the horizontal curves are expected to complete the deceleration manoeuvre on the tangent and transition curve and maintain a constant speed upon reaching the curve. However, this may not be true for the horizontal curves constituting a two-lane undivided rural highway passing through mountainous terrain. The objective of this study is to investigate the speed variability on a two-lane rural highway passing through mountainous terrain and to identify its determinants.