[Double blind placebo controlled randomized pilot clinical trial of baclofen (Baclosan®) for alcohol dependence].

Aim: To study efficacy and safety of baclofen for treatment of alcohol dependence.

Material And Methods: 32 patients with alcohol dependence had been randomized into one of two treatment groups (16 patients in each): patients of the 1st group were treated with baclofen (50 mg/day) for 3 months while patients of the 2nd one received identically looking placebo. All the study subjects were scheduled to come to the clinic on the weekly basis to control alcohol use and compliance with the study medications (by riboflavin marker in urine) and also - for psychiatric evaluations (severity of craving for alcohol, anxiety and depression).