Changes in levels of metabolic pathway gene expression under conditions of clear cell renal carcinoma.

A whole-transcriptome analysis of gene expression in six samples of clear cell renal cancer was performed. Using bioinformatics methods, we established a relationship between gene expression data and changes in activity of metabolic pathways: in this cancer type, the expression of genes involved in the metabolism of carbohydrates, lipids, and amino acids as well as in energy metabolism changed most significantly.

[The effect of fenofibrate on expression of genes involved in fatty acids beta-oxidation and associated free-radical processes].

Fenofibrate is a synthetic ligand for peroxisome proliferator-activated receptors subtype alpha (PPARa); it is used for the treatment of a wide range of metabolic diseases such as hypertriglyceridemia, dyslipidemia, diabetes and various neurodegenerative diseases. We have studied the effect of fenofibrate on b-oxidation of fatty acids and related free-radical processes. The most effective concentration of fenofibrate (0.

Mitochondrial energy-dissipating systems (alternative oxidase, uncoupling proteins, and external NADH dehydrogenase) are involved in development of frost-resistance of winter wheat seedlings.

Gene expression, protein synthesis, and activities of alternative oxidase (AOX), uncoupling proteins (UCP), adenine nucleotide translocator (ANT), and non-coupled NAD(P)H dehydrogenases (NDex, NDPex, and NDin) were studied in shoots of etiolated winter wheat (Triticum aestivum L.) seedlings after exposure to hardening low positive (2°C for 7 days) and freezing (-2°C for 2 days) temperatures. The cold hardening efficiently increased frost-resistance of the seedlings and decreased the generation of reactive oxygen species (ROS) during further cold shock.

[Renal function after radical nephrectomy].

For determination of indications and contraindications to radical treatment of renal cell carcinoma, it is necessary to have information about functional activity of renal parenchyma of the contralateral kidney while methods of examination predicting functional activity of postoperative renal parenchyma after radical nephrectomy are not recently available. The Russian Research Roentgenoradiology Center utilizes 99m-Tc-DMCA static scintigraphy for assessing renal parenchyma function. This radiopharmaceutical demonstrates the highest tropism for epithelium of the proximal convoluted tubules, most functionally active nephron segment.

[Cost effectiveness of screening for prostate cancer].

According to most experts, problems of prostate cancer (PC) have reached world-wide social and economic resonance at the turn of the 21st century. Costly programs of diagnosis and treatment of generalized PC and its complications require most spending. The general demographic situation and increased aging of male populations, both worldwide and in this country, make it clear that the total costs of medical aid to PC patients will inevitably grow.