Publications by authors named "V A Bashkirov"
Background: FLASH Radiotherapy (RT) is an emergent cancer RT modality where an entire therapeutic dose is delivered at more than 1000 times higher dose rate than conventional RT. For clinical trials to be conducted safely, a precise and fast beam monitor that can generate out-of-tolerance beam interrupts is required. This paper describes the overall concept and provides results from a prototype ultra-fast, scintillator-based beam monitor for both proton and electron beam FLASH applications.
View Article and Find Full Text PDFBackground: FLASH Radiotherapy (RT) is an emergent cancer radiotherapy modality where an entire therapeutic dose is delivered at more than 1000 times higher dose rate than conventional RT. For clinical trials to be conducted safely, a precise and fast beam monitor that can generate out-of-tolerance beam interrupts is required. This paper describes the overall concept and provides results from a prototype ultra-fast, scintillator-based beam monitor for both proton and electron beam FLASH applications.
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- Researchers have found that using alternating electric fields (100-300 kHz, 1-4 V/cm) can effectively slow down cancer growth in cell cultures and patients, a method known as tumor treating fields (TTFields).
- TTFields has been approved by the FDA for treating glioblastoma and malignant pleural mesothelioma, and early trials are exploring its effectiveness for other solid organ cancers.
- While TTFields alone shows similar survival rates to chemotherapy for recurrent glioblastoma, combining it with chemotherapy may extend survival by nearly 5 months for newly-diagnosed cases; further research in preclinical models is needed to enhance treatment delivery and effectiveness.
Interest in CRISPR-Cas12 and CRISPR-Cas13 detection continues to increase as these detection schemes enable the specific recognition of nucleic acids. The fundamental sensitivity limits of these schemes (and their applicability in amplification-free assays) are governed by kinetic rates. However, these kinetic rates remain poorly understood, and their reporting has been inconsistent.
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