[Electrophysiological mechanisms of the effect of allapinin in patients with paroxysmal supraventricular tachycardia].

An intracardiac electrophysiological study was undertaken to examine 15 patients with paroxysmal supraventricular tachycardias. Allapinin intravenously given in a dose of 0.4 mg/kg, was tested for effects.

[The anti-arrhythmia activity and effect on the heart conduction system of the new anti-arrhythmia preparation bonnecor].

In 10 patients with frequent ventricular extrasystoles there were studied the antiarrhythmic effectiveness and side effects of a new drug bonnecor at a single intravenous administration in doses from 15 to 60 mg (0.17-0.91 mg/kg).

[Comparative study of the effects of verapamil, ethmozin and ethacizine on provoked attacks of atrioventricular nodal reciprocal tachycardia].

27 patients underwent serial electrophysiological studies by using transesophageal atrial stimulation. A-V nodal reciprocal tachycardia was documented by intracardiac electrophysiological examinations. Sustained tachycardia was induced in all the patients before drug administration.

[A comparison of the results of endocardial and transesophageal electrostimulation of the heart in assessing sinus node function and atrioventricular conduction].

Forty five patients with cardiac arrhythmias were included in this study (20 had paroxysmal atrial fibrillation, 19, supraventricular tachycardias; 11 had sick sinus syndrome). In all patients endocardial electrophysiological study and transesophageal atrial pacing were performed in order to study sinus node function and atrioventricular conduction. The results of two methods of investigation have a high correlation.

[Effect of allapinin on the function of the atrioventricular conduction system of the heart].

The effect of allapinin on atrioventricular conductivity was assessed at intracardiac electrophysiologic investigation in 11 patients with various heart rhythm disorders. The effect of a 30 mg intravenous dose of the drug was evaluated 60 min after the injection. Allapinin significantly lengthened the P-Q interval and expanded the QRS complex.