[Estrogen receptors in the diagnosis and treatment of hormone-dependent tumors].

The paper presents the current data available on the etiology of tumor diseases, among other things, shows the role of hormones, namely: estrogens and their receptors, in the mechanism responsible for the occurrence of these diseases. Each tumor was shown to have its receptor status and to be unresponsive to this or that therapy differently. The efficiency of treatment and its prognosis may be determined if the receptor composition of an involved organ is estimated correctly.

[Physiological importance of numerous sex hormone receptors].

Numerous effects of sex hormones on the brain are mediated by interaction with intracellular steroid hormone receptors acting as regulators of transcription. These are the classical receptors ERalpha, ERbeta and ERgamma. Some estrogenic effects cannot be attributed to ERalpha or ERbeta, this suggests the existens of additional receptor subtypes.

[Receptor mechanisms of action of sex hormones. Can the receptor work without a ligand?].

Among endocrinologists, it is generally accepted that most of the effects of steroid hormones are transmitted to the cell through their receptors located on intracellular sites, mainly on the nuclei of cells, and these mechanisms are intensively studied. A lot of information has been accumulated about the specific function of each hormone, changes of which were observed after removal of the gland and its hormonal compensation. The basis of the position of endocrinologists in this situation is the fact that the removal of the gland eliminates many physiological and behavioral responses depending on the secretory function in this gland.

[Developmental stages of the Endocrinology Research Centre of the Russian Academy of Medical Sciences].

The article is devoted to the history of the development of the Endocrinology Research Centre.

[The influence of estrogens on the central nervous system].

The article is dedicated to the influence of sex hormones, especially estrogens, on the central nervous system. The author summarizes literature data and the results of his own research into the mechanism of estrogen action, both via cell receptors and neuromediator systems. The latter include cholinergic, catecholaminergic, and serotonergic systems of various brain structures, such as the hypothalamus, hippocamp, forebrain, substantia nigra etc.