[Immunogenetic blood markers as a risk factor of development of periodic disease in Armenian population].

Aim: To reveal characteristic associations between various markers of immunogenetic (HLA--A, B, C, DR), erythrocytic (ABO, Rh-Hr, MNSs, Pp, Kell-Chellano, Lewis), serum (Gm, Inv) systems and familial Mediterranean fever (FMF) in Armenian population.

Material And Methods: From 41 to 125 patients (depending on systems studied) were examined. HLA-antigens of A-, B-, C-classes were detected by the microcytotoxic test in a total population of lymphocytes, HLA-DR antigens--by a prolonged test in B-lymphocytes, erythrocytic antigens--by hemagglutination technique and indirect Coombs' reaction, serum antigens--by the method of hemagglutination suppression.

[Clinico-immunological parallels in children with periodic disease].

Children aged 3 to 15 years afflicted with periodic disease were subjected to clinical and immunological examinations. The role played by derangements of certain components of the immune system in the development and course of periodic disease was outlined. Assay of T lymphocytes and immunoglobulins of the main classes in the blood serum and saliva of children with periodic disease was found to be of the diagnostic and prognostic value.

[State of microcirculation homeostasis in children with rheumatism].

Microcirculatory homeostasis was studied in 107 children suffering from rheumatic fever. Conjunctival microcirculation and platelet aggregation were examined. The content of circulating immune complexes and medium-size molecules was measured in the blood.