Publications by authors named "V A Aniol"

Aging is a complex process associated with multimorbidity. Hypertension, one of widespread states, is among main causes of age-related alterations in behavior, emotionality and sociability. We studied the effects of long-term isolated housing on anxiety, depressive-like and social behavior as well as changes in the adrenocortical and sympathetic systems in the aging normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR).

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A delicate balance between quiescence and division of the radial glia-like stem cells (RGLs) ensures continuation of adult hippocampal neurogenesis (AHN) over the lifespan. Transient or persistent perturbations of this balance due to a brain pathology, drug administration, or therapy can lead to unfavorable long-term outcomes such as premature depletion of the RGLs, decreased AHN, and cognitive deficit. Memantine, a drug used for alleviating the symptoms of Alzheimer's disease, and electroconvulsive seizure (ECS), a procedure used for treating drug-resistant major depression or bipolar disorder, are known strong AHN inducers; they were earlier demonstrated to increase numbers of dividing RGLs.

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Brain aging is associated with a progressive decrease in learning abilities, memory, attention, decision making, and sensory perception. Age-related cognitive disturbances may be related to a decrease in the functional capacities of the hippocampus. This brain region is essential for learning and memory, and the lifelong neurogenesis occurring in the subgranular zone of the dentate gyrus may be a key event mediating the mnemonic functions of the hippocampus.

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Article Synopsis
  • - NMDA receptor antagonists show potential in treating various central nervous system disorders, including major depressive disorder, and this study focuses on optimizing a specific biphenyl-based NMDA negative allosteric modulator (NAM).
  • - The optimization process, guided by free energy calculations, resulted in a significant increase in activity, improving the compound's effectiveness by 100 times (IC = 50 nM) compared to an initial hit found through virtual screening.
  • - Preliminary results indicate this optimized NAM has low affinity for the hERG ion channel, an earlier hurdle for similar compounds, and it exhibits a unique binding mode that differs from another related NMDA NAM called EVT-101.
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Article Synopsis
  • * Early life stress can disrupt the maturation of neurons and glial cells in the DG, leading to long-term structural and functional changes that may contribute to mental health issues later on.
  • * The review highlights that while initial cellular stress responses may fade, lasting genetic changes persist, and additional life stressors can exacerbate behavioral problems linked to these early developmental disruptions.
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