[A search for microscopic fungi with directed hydroxylase activity for the synthesis of steroid drugs].

The hydroxylase activities of new strains such as Curvularia lunata, C. geniculata, C. eragrostidis, C.

[Novel Immobilized Biocatalyst for Microbiological Synthesis of Pharmaceutical Steroids].

The steroid-transforming activity of free and immobilized cells of Pimelobacter simplex VKPM As-1632 entrapped in an operationally stable macroporous polyvinyl alcohol cryogel was studied. It was shown that the macroporous matrix of the carrier did not create any diffusional limitations for steroid access to the cells or the removal of the transformation products from them. The optimal conditions for the hydrocortisone 1,2-dehydration into prednisolone by free and immobilized cells were elucidated.