[MAJOR MOLECULAR AND CELLULAR MANIFESTATIONS OF ATHEROSCLEROSIS].

The authors consider machanisms and peculiarities of development of atherosclerosis at the tissue level and the main characteristics of atherogenesis, viz. lipoidosis, fibrosis, enhanced intimacyte proliferation, local intima-media thickening. Results of counting subendothelial cells, assessment of their proliferative and synthetic activities in affected and intact arterial segments are presented Variants of lipid metabolism disorders are described.

[Direct antiatherosclerotic therapy: possible approaches, results of clinical trials].

The paper discusses the main approaches to slowing the progression and epy regression of atherosclerosis. Lipid and non-lipid treatment of atherosclerosis described. The results of clinical studies of the effect of antiatherosclerotic agents are analyzed.