Publications by authors named "V A Ageevets"
Carbapenem-resistant (CRE) are a global health threat due to their high morbidity and mortality rates and limited treatment options. This study examines the plasmid-mediated transmission of virulence and antibiotic resistance determinants in carbapenem-resistant () and () isolated from Russian hospitals. : We performed short- and long-read whole-genome sequencing of 53 clinical isolates (48 and 5 ) attributed to 15 genetic lineages and collected from 21 hospitals across nine Russian cities between 2016 and 2022.
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- The study focuses on the role of mobile genetic elements in spreading biocide and antibiotic resistance among bacteria, specifically the qacEΔ1 gene that provides resistance to quaternary ammonium compounds (QACs).
- Researchers developed a TaqMan real-time PCR assay to detect the qacEΔ1 gene in Gram-negative bacteria, which can accurately identify even low quantities (as few as 80 copies) without false results.
- This assay serves as a rapid, sensitive, and specific method for monitoring QAC resistance, tracking the spread of class 1 integrons, and predicting multidrug-resistant (MDR) traits in Gram-negative bacteria.
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- Dose-intensive therapies during allogeneic hematopoietic stem cell transplantation (allo-HSCT) significantly disrupt gut microbiota and promote antibiotic resistance, with recovery patterns poorly understood.
- In a study of 12 adult patients, stool samples revealed a marked decline in microbial diversity starting from day 0, persisting for up to a year, with specific bacterial genera showing slower recovery.
- A rise in antibiotic-resistant bacteria was observed around day 30 post-transplant, with resistance to major antibiotic classes, but a gradual decrease in resistance levels was noted over the following year.
This study was aimed at understanding the distributions of the MICs (minimum inhibitory concentrations) of aztreonam-avibactam, ceftazidime-avibactam and meropenem with respect to Klebsiella pneumoniae isolates producing different types of carbapenemases and their combinations. K. pneumoniae isolates were collected between 2019 and 2022 from 37 hospitals.
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- * A study analyzed 696 URT samples from 285 COVID-19 patients and 100 healthy controls, revealing significant differences in microbial composition, with COVID-19 patients showing reduced abundance of 16 bacterial genera and unique taxa not found in healthy individuals.
- * As COVID-19 patients underwent treatment, certain depleted bacteria (like Fusobacterium and Neisseria) increased, suggesting recovery as their URT microbiome composition began resembling that of healthy individuals, indicating a shift towards stability.