Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Spinal dorsal horn neurons involved in the alleviating effects of cannabinoid receptor agonists on neuropathic allodynia-like behaviors in rats.

Mechanical allodynia, the pain caused by innocuous tactile stimuli, is a hallmark symptom of neuropathic pain that is often resistant to currently available treatments. Cannabinoids are widely used for pain management; however, their therapeutic mechanisms for neuropathic mechanical allodynia remain unclear. Using transgenic rats that enable to optogenetically stimulate touch-sensing Aβ fibers in the skin, we found that the intrathecal administration of the synthetic cannabinoid, WIN 55,212-2, alleviated the Aβ fiber-derived neuropathic allodynia.

First record of infection in (Rodentia: Muridae) in Tokunoshima Island, Japan.

The Ryukyu long-furred rat, (Rodentia: Muridae), is an endangered species endemic to the Tokunoshima, Amami-Oshima, and Okinawajima Islands, which are part of Japan's southwestern islands. During the pathological examination of a deceased wild individual from Tokunoshima Island, lymphoma and infection with three nonnative parasites, (Nematoda: Angiostrongylidae) (Nematoda: Trichosomoididae) and (Cestoda: Taeniidae), were identified. Among these, is a zoonotic species, with invasive rats as the final hosts and mollusks as intermediate hosts.

Relationship of Desmoplastic Reaction and Tumour Budding in Primary and Lung Metastatic Lesions of Colorectal Cancer and Their Prognostic Significance.

Histopathological indicators, including desmoplastic reaction (DR) and tumour budding (TB), are significant prognostic indicators for metastatic liver lesions in patients with colorectal cancer (CRC). However, the relationship of DR and TB in primary CRC and metastatic lung lesions and their prognostic significance has not yet been examined. This study aimed to elucidate the association of DR and TB in primary CRC and metastatic lung lesions.

HepG2 cells do not express xanthine oxidoreductase (XOR): Implications for XOR and uric acid-related research.

Although the relative extent of xanthine oxidoreductase (XOR) varies considerably in human tissues, the greatest specific activity is reported in the liver and intestines. Unlike murine models, where primary hepatocytes are readily available, human counterparts are not. As such, investigators often utilize the human carcinoma cell line HepG2 for in vitro experimentation as these cells proliferate well in culture medium.

[Aicardi-Goutieres syndrome type 6 associated with a compound heterozygous variant in ADAR: a first case report in the Russian population].

Aicardi-Goutieres syndrome (AGS) is a rare hereditary disorder with different types of inheritance manifested by progressive leukoencephalopathy with early onset, sharing common features with autoimmune disease. This article describes the first Russian case of AGS type 6 (AGS6) associated with compound heterozygote c.577C>G (p.

Differential Expression of Hard Tissue Proteins in Hypomineralized Second Primary Molars in Comparison to Normal Teeth.

Objective: This study aims to identify the proteins in hypomineralized second primary molars (HSPMs) and correlate their function in Amelogenesis. HSPM is a qualitative defect of the enamel of the second primary molars with no clear etiology.

Material And Methods: Total protein quantification was performed using the Bradford Protein Assay, followed by the electrophoretic separation of samples using 2D-Gel electrophoresis to identify the proteins.

Evaluating the Efficacy of Siddha Pharmacotherapy for Acrochordon: A Case Report.

Skin tags, medically known as acrochordons, are harmless growths of the epidermis that commonly develop in areas where the skin folds, such as the neck, armpits, or groin. While usually asymptomatic, these lesions can cause discomfort from rubbing or cosmetic issues. They are more prevalent in middle-aged and older individuals and are often correlated with conditions such as obesity, diabetes, and insulin resistance.

The nucleolin antagonist N6L and paclitaxel combination treatment could be a new promising therapeutic strategy for pancreatic ductal adenocarcinoma therapy.

Pancreatic cancer (PCa) is one of the most devastating cancers with few clinical signs and no truly effective therapy. In recent years, our team has demonstrated that nucleolin antagonists such as N6L could be a therapeutic alternative for this disease. In order to study a possible clinic development of N6L (multivalent pseudopeptide), we undertook to study the effect of combination of N6L with chemotherapies classically used for PCa on the survival of pancreatic cancer cells.

The effect of a 14-day Gymnema sylvestre intervention to reduce sugar intake in people self-identifying with a sweet tooth.

Gymnema sylvestre (GS) contains gymnemic acids which can reversibly suppress sweet taste responses. This randomised crossover study aimed to investigate whether supplemental GS use can reduce sugar cravings, sweet food desire and consumption among adults that identify as high sweet food consumers (having a 'sweet tooth'). Participants were told three different mints were trialled to avoid bias.

Role of procalcitonin, C-reactive protein and ferritin in cytokine release syndrome after CAR T-cell therapy in children and young adults.

Purpose: Chimeric antigen receptor (CAR) T-cell CD19 therapy has changed the treatment paradigm for patients with relapsed/refractory B-cell acute lymphoblastic leukemia. It is frequently associated with potentially severe toxicities: cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and admission to PICU is often required. Some biomarkers seem to correlate with CRS severity.

Enhanced diabetic retinopathy detection using U-shaped network and capsule network-driven deep learning.

Glaucoma, a severe eye disease leading to irreversible vision loss if untreated, remains a significant challenge in healthcare due to the complexity of its detection. Traditional methods rely on clinical examinations of fundus images, assessing features like optic cup and disc sizes, rim thickness, and other ocular deformities. Recent advancements in artificial intelligence have introduced new opportunities for enhancing glaucoma detection.

Luminescent ZnSe/ZnO Heterostructures for Photocatalytic Degradation of Azophloxine Dye and Bioimaging Applications.

Herein, we demonstrate a simple hydrothermal route to synthesizing ZnSe/ZnO type II heterostructure using L-cysteine as a capping agent. The use of nanomaterials in bioimaging and photocatalysis towards the degradation of Azophloxine dye is of potential interest. The synthesized ZnSe/ZnO nanomaterials were characterized by UV-Vis absorption spectroscopy, fluorescence spectroscopy, IR spectroscopy, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy.

Sensorless vector-controlled induction motor drives: Boosting performance with Adaptive Neuro-Fuzzy Inference System integrated augmented Model Reference Adaptive System.

The Model Reference Adaptive System (MRAS) is effective for speed control in sensorless Induction Motor (IM) drives, particularly at zero and very low speeds. This study enhances MRAS's resilience and dynamic performance by integrating an Adaptive Neuro-Fuzzy Inference System (ANFIS) controller into sensorless vector-controlled IM drives. The research addresses challenges related to parameter uncertainties, load variations, and external disturbances through the combination of MRAS and ANFIS.

A novel dual hysteresis controller for the management of a three phase dynamic voltage restorer.

In this work a novel control scheme for the three-phase dynamic voltage restorer has been proposed and validated. The proposed control strategy guarantees the source current waveform to be sinusoidal and at near unity power factor. Further, the voltage sag and swell occurring in the source are overcome and the load gets a smooth power supply at a voltage closer to the rated voltage even in the face of voltage sag or swell occurring in the source.

Prevalence of Nutritional Anaemia in Type 2 Diabetes Mellitus in the Absence of Renal Impairment.

Background: Anemia is more common in people with type 2 diabetes mellitus (T2DM) and is more likely when glycemic control is poor. Anemia in T2DM can reduce quality of life and increase cardiovascular risk, and therefore, its prevalence and contributory factors in diabetic patients with normal kidney function are important to understand.

Aim And Objectives: The aim of this study is to assess the prevalence of anemia in individuals with type 2 diabetes and normal kidney function, focusing on blood glucose, serum creatinine, HbA1c, hemoglobin, and hematocrit levels.

Radiometric evaluation of Ouratea miersii (Planch.) Engl. From the Municipal Natural Park of Niterói, Brazilian Atlantic Rainforest remnant.

Concern about radiation exposure to non-human biota and the environment has increased since the 1990s, resulting in several publications by UNSCEAR, IAEA, ICRP, among other agencies, which highlighted significant gaps in knowledge regarding non-human biota and resulted in the establishment of Reference Animals and Plants (RAPs). In Brazil, the Atlantic Forest biome has vast biodiversity, but there is a lack of information on the radiometric profile of plant species growing there. Thus, the objective of this study was to evaluate the radiometric profile of Ouratea miersii (Malpighiales), endemic to the Atlantic Rainforest, collected in the State of Rio de Janeiro, city of Niterói, at the Municipal Natural Park (PARNIT), which covers a region of protected Atlantic Rainforest.

Deterioration of the Defecation Status after Hospitalization in Patients with Type 2 Diabetes is Associated with Albuminuria Rather than Diabetic Neuropathy.

Objective To determine the clinical background factors of patients with type 2 diabetes who showed deterioration of defecation status after hospitalization. Methods The defecation status of 128 patients with type 2 diabetes who were admitted to our department for diabetes education was evaluated for 7 days after hospitalization. New-onset constipation was diagnosed when patients without constipation before hospitalization met the criteria for constipation after hospitalization.

A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats.

Caprine livestock are significant reservoirs of the complex (MTBC), contributing to tuberculosis (TB) transmission among animals and humans. The P22 protein immunocomplex (P22PI), derived from bovine tuberculin, shows immunostimulating capacity and is used for TB diagnosis. This study assessed the immunogenicity and protective efficacy of P22PI in two groups of goats: 24 naïve goats (12 immunised, 12 controls) from a TB-free herd, and 24 infected goats (12 immunised, 12 controls), referred to as pre-infected animals, from a -infected herd.

Effect of Baseline Values of Renal Prognosis-related Factors on Their Changes after Initiating Tofogliflozin Treatment: A Retrospective Study in Japanese Patients with Type 2 Diabetes and Renal Impairment.

Introduction: This study investigated the relationships between changes in renal prognosis-related factors after initiating tofogliflozin and the corresponding baseline values in clinical practice in Japanese patients with type 2 diabetes.

Methods: We investigated the relationships between changes in hematocrit, hemoglobin, systolic blood pressure (sBP), urinary protein excretion (uPE), serum uric acid (sUA), and estimated glomerular filtration rate (eGFR) 12 months after initiating tofogliflozin (20 mg) and their corresponding baseline values in 130 patients with type 2 diabetes. The subjects were divided into two groups: normal (≥60 mL/min/1.

Evaluating the Crossmatch-to-Transfusion Ratio as a Tool for Analyzing and Optimizing Blood Bank Resource Utilization: A Retrospective Observational Study.

Background Blood transfusion services are crucial for modern medical care, particularly for surgical interventions, chronic diseases, pregnancy complications, and malignancies. There is an increasing demand for blood products in India; hence, optimizing resource utilization in blood banks is essential. This study aims to evaluate the crossmatch-to-transfusion (C/T) ratio as a tool for analyzing and optimizing the utilization of blood bank resources.

Impact of Type and Screen Method on Turnaround Time and Man-Hour Utilization Compared to Conventional Coomb's Crossmatch: A Cross-Sectional Analytical Study.

Background Blood component transfusion is vital for various medical conditions, requiring thorough pretransfusion testing to ensure safety and compatibility. The Type and Screen (T and S) method allows for efficient detection of clinically significant antibodies while reducing unnecessary crossmatching. This study evaluates T and S's impact on turnaround time and man-hour utilization compared to conventional crossmatching.

Activity-based contracting for optimization of the mass distribution of insecticide-treated nets in the Democratic Republic of Congo: pilot implementation in Kwilu province.

Background: Promoting the use of insecticide-treated mosquito nets (ITNs) is one of the main strategies for reducing malaria-related morbidity. An innovative activity-based contracting (ABC) approach has been implemented in Kwilu Province, Democratic Republic of Congo to optimize ITN mass distribution campaigns, with payments based on contractually defined programmatic outcomes for key campaign activities following independent verification of results.

Methods: This internal evaluation was carried out using a mixed methods approach combining qualitative and quantitative document and content analysis from a series of three workshops: validation workshops for campaign results at provincial level for the 2021 and 2022 campaigns; internal evaluation workshop for the Kwilu campaign as part of the ABC approach organized by "Santé pour tous en milieu rural" (SANRU) with its sub-contractors; and national campaign evaluation workshop organized by the National Malaria Control Program.