Mutational screening of GDAP1 in dysphonia associated with Charcot-Marie-Tooth disease: clinical insights and phenotypic effects.

Introduction: Mutations in GDAP1 (Ganglioside-induced differentiation-associated protein 1) gene are linked to Charcot-Marie-Tooth disease (CMT), a Heterogenous group of disorders with multiple phenotypes, characterized by peripheral nerve dysfunction that can lead to vocal cord paralysis and diaphragmatic dysfunction.

Main Body: All three affected children of this chosen family have manifested the same clinical symptoms with progressive weakness, mild sensory impairment, and absent tendon reflexes in their early years. Electrodiagnostic analysis displayed an axonal type of neuropathy in affected patients.

Ecotoxicity of neonicotinoids and diamides on population growth performance of Zygogramma bicolorata (Coleoptera: Chrysomelidae).

Relative ecotoxicity of approved neonicotinoids (i.e. imidacloprid, clothianidin, acetamiprid, thiacloprid, thiamethoxam and dinotefuran) and diamides (i.