Nicolai Kravkov's pancreotoxine.

The article reviews the life and work of an outstanding Russian pharmacologist Professor Nikolai Kravkov (1865-1924). Among his many scientific achievements, he worked on an extract from the pancreas of animals in the early 1920s and was successful in isolating the internal secretion, which he named "pancreotoxine." This reduced blood glucose levels in animals and diabetic humans.

[At the origin of the development of russian angiology (dedicated to the 150 birthday of academician N.P. Kravkov)].

The article describes scientific activity of outstanding pharmacologist, Academician N.P. Kravkov (1865-1924) on studying dynamics of the vascular system in experiment: Using the method of isolated animal organs of animals, N.

[Academician Nikolai Pavlovich Kravkov: on his 150th birthday].

The article outlines the life and activities of academician N. P. Kravkov (1865-1924), the founder of pharmacology in Russia.

[V.P. Kravkov as a sanitary physician of the Russian Imperial Army (to centenary of beginning of the First World War)].

The article presents for the first time the description of life story and service of V.P. Kravkov (1859-1920)--participant of Russian-Japanese war and the First World War, doctor of medicine, sanitary physician of the Russian Imperial Army and author of number of books and articles on preventive medicine.

In vivo analysis of antioxidant and prooxidant properties of retinol acetate.

Analysis of the effects of retinol acetate on LPO processes in vivo revealed antioxidant effects under normal conditions and during experimental free-radical pathology (toxic hepatosis-hepatitis). The concentration inversion of antioxidant effects of retinol acetate into prooxidant effects were observed only under normal conditions.

[Hepatoprotectors in treatment of alcoholic liver disease].

The best hepatoprotective effect has combined appointment Essentiale forte N, Heptral and Apilak at rats with chronic alcohol intoxication. Use of these drugs is characterized by minor morphological changes in structure of liver and constant biochemical parameters.

[The antioxidant properties of parmidine in a toxic lesion of the liver].

The experiments on rats with toxic lesions of the liver induced by tetrachlorinemethane showed that parmidine (pyridinolcarbamat) promotes the reduction of the activity of lipid peroxidation in the liver tissue homogenates and erythrocytes. The pronounced tendency towards normalization of free-radical oxidation correlated with the positive dynamics of the histological picture of the liver.

[On the 125th anniversary of the birth of academician N. P. Kravkov].

The article deals with the description of the life and activities of the founder of the Soviet pharmacology Academician N. P. Kravkov.

[The effect of parmidine on the lipid peroxidation processes in coronary atherosclerosis].

During the formation and development of atherosclerosis the intensity of lipid peroxidation and the activity of antioxidant defence system significantly change. The use of parmidine decreases the contents of primary and secondary products of lipid peroxidation, reduces peroxide hemolysis of erythrocytes and increases the content of reduced glutathione in erythrocytes of patients with atherosclerosis. This shows that parmidine possessing the antioxidant properties stabilizes lipid peroxidation processes and normalizes the physiological antioxidant system.

[The effect of testosterone propionate on energy metabolism indices and the catecholamine content of the vascular wall].

The effect of testosterone propionate (1 mg/kg) on the specific activity of lactate dehydrogenase, malate dehydrogenase, contents of pyruvic and lactic acids, levels of catecholamines in target tissues and non-target tissues of rats was studied. Deficit of androgens and their single compensation by administering testosterone propionate lead to an inhibition of energy formation, a decrease of enzyme activity and contents of metabolites in tissues of the seminal vesicles. The course administration of testosterone propionate increases the activity of malate dehydrogenase in the aorta and myocardium.

[Aminazine distribution in the organs and tissues of rats depending on the routes of administration and the age of the animals].

Distribution of intramuscular and oral aminazin (20 mg/kg) in the brain, lungs, liver, kidneys, heart, ileum, blood and urine was studied in young and old male rats. Intramuscular drug showed maximal accumulation in the lungs and intestine, respectively, whereas at oral administration maximal and minimal accumulation was recorded in the liver and kidneys. Urine excretion of parenteral aminazin was 4-7-fold higher as compared to oral administration.