Corneal perforation in ocular graft-versus-host disease.

Purpose: Corneal perforation is a rare, vision-threatening complication of ocular graft-versus-host disease (GVHD) and is not well understood. Our objective was to examine the clinical disease course and histopathologic correlation in patients who progressed to this outcome.

Methods: This study is a retrospective case series from four academic centers in the United States.