Publications by authors named "Uwe Mortensen"
Background And Objective: Previous studies have shown that the use of optical coherence tomography (OCT) permits the differentiation between parathyroid tissue, thyroid tissue, lymph nodes and adipose tissue. We investigated the backscattering intensity profiles of OCT images in order to determine whether significant differences between these tissue types exist.
Methods: Mean backscattering intensity profiles were obtained from OCT images of parathyroid glands, thyroid tissue, lymph nodes and adipose tissue.
Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in order to detect precancerous and cancerous cervical lesions. Optical clearing agents (OCAs) temporarily reduce the optical scattering of biological tissues. The purpose of this study was to investigate their influence on OCT imaging.
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- This study explored the impact of acetic acid on optical coherence tomography (OCT) imaging for identifying precancerous and cancerous cervical lesions during colposcopy.
- OCT images taken immediately, and 3 and 10 minutes after acetic acid application showed significant changes, like increased brightness and scanning depth, but decreased contrast in normal epithelium after 10 minutes.
- The findings suggest that acetic acid enhances the quality of OCT images, which could improve the detection of cervical lesions, though the effects on image contrast vary depending on the tissue type.
Objective: To establish and validate an ex vivo human cervical tissue model for optical coherence tomography (OCT) studies with special emphasis on investigating time dependent structural changes of the epithelium.
Methods: Four hundred OCT images were taken from 80 unsuspicious and suspicious areas of 18 fresh conisation specimens immediately after resection (0 hour) and 1, 2, 3, and 4 hours, referred to as waiting times in the following, postoperatively and compared to the corresponding histology. For each 2D-OCT-image, a 1D-intensity profile was generated.