The health of populations living in the indigenous minority settlements of northern Yakutia.

This monograph contains the results of a study carried out by the Yakutsk Research Center for Complex Medical Problems, "Evaluating the health of the indigenous minorities of the Sakha Republic (Yakutia) and optimizing medical assistance using innovative technologies and telemedicine in indigenous settlements." The child population was studied in 19 indigenous minority settlements, and the adult population was studied in 12 settlements.

Health status of Native people living in the Republic of Sakha (Yakutia).

Background: Native people of the Republic of Sakha (Yakutia) live mostly in northern regions in the so-called "national settlements". Natives usually experience more health-related problems as compared to the total population. As a result, life expectancy at the birth of Natives living in the Republic of Sakha (Yakutia) is lower compared to ethnic groups living in European countries, in the United States, and in Canada.

Response of mononuclear phagocyte system to experimental tuberculosis in mice of opposite strains.

Genetically determined peculiarities of the reaction of the mononuclear phagocyte system to BCG vaccine manifested in CBA and C57Bl/6 mice by differences in the number and size of granulomas and time course of changes in the cellular composition of granulomas, peripheral blood, and bone marrow.

[Intensive chemotherapy tolerance in old patients with pulmonary tuberculosis].

In accordance with the WHO recommendations, the intensive stage of chemotherapy was performed in 100 patients aged 60 to 87 years who had pulmonary tuberculosis. Most (n = 78) patients successfully completed this stage and the remaining 22 patients developed intractable adverse reactions and they had to receive individual chemotherapy regimens. In addition, 27 more patients had adverse reactions that could be eliminated by routine methods, without discontinuing standard treatment.

[Efficiency of an intensive stage of chemotherapy for tuberculosis in elderly and senile patients].

A hundred new cases of active pulmonary tuberculosis whose age was 60 to 87 years were treated by the intensive chemotherapy regimen recommended by the WHO. Most (n = 78) patients satisfactorily tolerated the intensive stage, fully completed the regimen, and made up a study group (Group 1). Group 2 comprised the remaining 22 patients who had, due to its poor tolerance, to transfer to their individual regimen.

On the origin of a sustained increase in cytosolic Ca2+ concentration after a toxic glutamate treatment of the nerve cell culture.

A sustained increase of cytosolic Ca2+ concentration, [Ca2+]i, (Ca2+ plateau) was induced by a 15-min treatment with 50 microM glutamate of cultured cerebellar granule cells and hippocampal neurons in a Mg(2+)-free solution. Plateau proved to be insensitive to inhibition of Na+o/Ca2+i exchange caused by removal external Na+ in the post-glutamate period. A approximately 10(5)-fold reduction of [Ca2+]o (from 1.

[Changes in the incorporation of labeled amino acids into separate protein fractions of the cerebral tissue in rats after intrauterine hypoxia].

Incorporation of 14C-amino acid mixture into the cortex and cerebellum protein was studied in 7, 15, 30 days old rats after prenatal hypoxia. Prenatal hypoxic rats was shown to have alteration of the pattern of incorporation of label predecessors into brain protein. Prenatal hypoxia led to significant decrease of incorporation value at 30,000 molecular weight fractions.