Ternary Association Reaction of Vibrationally Cold N Ions in Ambient Helium.

The rate coefficients for the ternary association reaction of vibrationally cold N ions with N and He were measured in an afterglow plasma in the temperature range of 140-250 K: = (1.02 ± 0.39)(300/) × 10 cm s.

Overtone Transition 2ν of HCO and HOC: Origin, Radiative Lifetime, Collisional Quenching.

We present spectra of the first overtone vibration transition of C-H/ O-H stretch (2ν) in HCO and HOC, recorded using a laser induced reaction action scheme inside a cryogenic 22 pole radio frequency trap. Band origins have been located at 6078.68411(19) and 6360.

Recombination of vibrationally cold N2+ ions with electrons.

Recombination of vibrationally cold N2+ ions with electrons was studied in the temperature range of 140-250 K. A cryogenic stationary afterglow apparatus equipped with cavity ring-down spectrometer and microwave diagnostics was utilized to probe in situ the time evolutions of number densities of particular rotational and vibrational states of N2+ ions and of electrons. The obtained value of the recombination rate coefficient for the recombination of the vibrational ground state of N2+ with electrons is αv=0 = (2.

[The increased sensitivity of dentin: the mechanisms of remineralization using toothpaste with tin fluoride].

The purpose of the study was clinical and laboratory analysis of the remineralizing properties and clinical efficacy of the course application of the Sensodyne Rapid Relief therapeutic and prophylactic toothpaste for sensitive teeth with tin fluoride. The study involved 50 overwise healthy patients aged from 18 to 25 years diagnosed with a localized form of hyperesthesia of hard dental tissues and no signs of acute inflammation of periodontal tissues. After 7 days of clinical observation and daily use of the toothpaste the hygienic condition of the oral cavity in all patients improved: oral hygiene index was 1.

[Further evidence that the serotonin transporter gene is associated with schizotypal traits in a healthy Russian population].

Genetic factors are thought to contribute to schizotypal dimensions. Recently, a number of genetic variants associated with schizotypal traits in psychiatrically healthy people have been found. Authors reported earlier the association between the SERT 5-HTTLPR polymorphism and schizotypal traits measured with MMPI.

[Association between the Val66Met polymorphism of brain-derived neurotrophic factor gene and schizophrenia in Russians].

Recent studies have demonstrated a role of the brain-derived neurotrophic factor (BDNF) in schizophrenia. An association between the Val66Met BDNF polymorphism has been reported but the results of different studies are inconsistent. An aim of the present article is to study the allele and genotype distribution in patients with schizophrenia (783) and mentally healthy controls (633).

Changes in EEG spectral power on perception of neutral and emotional words in patients with schizophrenia, their relatives, and healthy subjects from the general population.

EEG correlates of impairments in the processing of emotiogenic information which might reflect a genetic predisposition to schizophrenia were sought by studying the dynamics of EEG rhythm powers on presentation of neutral and emotional words in 36 patients with schizophrenia, 50 of their unaffected first-degree relatives, and 47 healthy subjects without any inherited predisposition to psychoses. In controls, passive hearing of neutral words produced minimal changes in cortical rhythms, predominantly in the form of increases in the power levels of slow and fast waves, while perception of emotional words was accompanied by generalized reductions in the power of the alpha and beta(1) rhythms and regionally specific suppression of theta and beta(2) activity. Patients and their relatives demonstrated reductions in power of alpha and beta(1) activity, with an increase in delta power on hearing both groups of words.

[Changes in the EEG spectral power during perception of neutral and emotionally salient words in schizophrenic patients, their relatives and healthy individuals from the general population].

To search for EEG-correlates of emotional processing that might be indicators of genetic predisposition to schizophrenia, changes in EEG spectral power during perception of neutral and emotionally salient words were examined in 36 schizophrenic patients, 50 of their unaffected first-degree relatives, and 47 healthy individuals without any family history of psychoses. In healthy persons, passive listening to neutral words induced minimum changes in cortical rhythmical activity, predominantly in the form of synchronization of slow and fast waves, whereas perception of emotional words was followed by a generalized depression of the alpha and beta1 activity and a locally specific decrease in the power of theta and beta2 frequency bands. The patients and their relatives showed a decrease in the alpha and beta1 activity simultaneously with an increase in the power of delta activity in response to both groups of words.

[Peculiarities of EEG dynamics in cognitive activity demanding persistent attention in patients with schizophrenia and schizoaffective psychosis and their relatives].

The search for neurophysiologic correlates of attention and working memory dysfunction in families with schizophrenia, 55 patients with schizophrenia and schizoaffective psychosis, 91 unaffected first degree relatives and 48 mentally normal subjects without family history of mental disorders have been studied. Changes in power of 5 EEG frequency bands in 16 records during serial mental arithmetic tasks were analyzed. Abnormalities in EEG reactivity were found both in patients and their relatives.

Cognitive peculiarities in relatives of schizophrenic and schizoaffective patients: heritability and resting EEG-correlates.

The role of genetic factors in liability to schizophrenia is well established. It is supposed that different susceptibility genes produce distinct neurobiological and behavioural phenotypes that may each increase the risk for developing schizophrenia. The aim of the study was to search for genetically and pathophysiologically independent domains of mild cognitive disturbances that might be the components of liability to schizophrenia.

[Neuromorphologic and psychological correlates of electrical brain activity in patients with schizophrenia and their relatives].

The study aimed at elucidation of potential correlations between EEG features, neuromorphologic and psychological characteristics in patients with schizophrenia and in subjects with familial predisposition to the disease. EEG has been conducted in 71 patients, 162 first-degree relatives of schizophrenia subjects and 67 healthy controls. In the patients and relatives, correlations of power indices for 7 frequency ranges of resting EEG with computed tomography and cognitive parameters were analyzed.

[The genetic aspects of the neuropsychology of verbal memory in schizophrenia].

Genetic study methods were used while examining the families with schizophrenic patients to study the relationships between computerized tomographic and resting ECG parameters with memory for information, which differed in degrees and ways of organization. In patients, memory performance was affected both by genotype-controlled high-frequency alpha-rhythm subranges and by integral delta-rhythm values determined by environmental factors. A significant role of the right hemisphere was found for all forms of remembering.

[A multivariate genetic analysis of the data from a complex study of the predisposition to schizophrenia].

49 families of schizophrenics (49 probands and their 106 first-degree relatives) were studied by means of psychological methods, EEG and computed tomography. Multivariate genetic analysis were performed to assess genetic and environmental components of parameter phenotypic variance and relations between the parameters and liability to schizophrenia, including formation of discriminant functions for classification of individuals into high risk and normal groups and estimation of the functions heritability. Besides, correlations between parameters of neuromorphological, neurophysiological and psychological levels were calculated.

[Genetic analysis of the resting EEG parameters of schizophrenics and their relatives].

The heritability of the resting EEG parameters was studied in 45 schizophrenic families. In offspring--parent pairs (N = 94) and sibs pairs (N = 27) high correlation of average power values of frequency bands between relatives was found (r > 0.5 for alpha and beta power; r 0.

Neurophysiological and psychological predictors of genetic risk for schizophrenia.

Mathematical genetic analyses were performed on a sample of schizophrenic families (25 probands and 58 first-degree relatives). Heritability coefficients were estimated for EEG power spectrum parameters and their topography, and also for psychological test data on thought and speech process disorder, designed to assess altered selectivity in cognitive activity. Multiple regression equations for genetic counseling regarding the prognosis of mental illness were derived from the neurophysiological and psychological measures.

[Correlation of the clinical pharmacological action of a single dose of fenazepam with the EEG dynamics and pharmacokinetics].

Interaction between the clinical, EEG-effects and phenazepam concentration in the blood was studied in 111 patients with neurotic disorders after intake of the test drug dose (2 mg) administered singly and on the 14th day of the treatment. It was established that EEG changes commonly induced by benzodiazepines supervene primarily within the interval of 1 to 3 h after a single intake which correlates with the maximal degree of the tranquilizing, somnolent and myorelaxant drug action. It was demonstrated that the clinical and EEG-effects occur before attainment of the maximal phenazepam concentration and then become less potent, with preservation of the high blood drug level.

[Relation between the dynamics of EEG indices after a single dose of the tranquilizer phenazepam and its efficacy during a course of treatment of patients with borderline neuropsychological disorders].

The effect of a single phenazepam dose (1-2 mg) on the power of EEG frequency ranges, their interhemispherical asymmetry and the level of intra- and inter-hemispherical correlations was studied in 78 patients with borderline neuropsychic disturbances divided into four groups depending on the efficiency of phenazepam therapy. Different variants of reactions of EEG parameters related to the characteristics of the clinical action of the drug in different groups of patients were identified. High therapeutical efficacy of phenazepam was associated with a complex of bilateral, relatively generalized changes in power of beta- and alpha-ranges, characteristic of action of benzodiazepins and combined with a predominantly right-side decrease in theta-range and the absence of any significant dynamics of the initially intact correlations of the EEG.

[Relation between the effect of tranquilizers and various features of personality structure among patients with borderline states].

The authors revealed differences in the clinico-psychopathological structure, therapeutic time-course and efficiency of the treatment by tranquilizers (e. g. phenazepam, a drug whose effect is typical for the entire group of tranquilizers) in 86 patients with borderline states, the nature of differences depending on the typological characteristics of their personality structure.