Publications by authors named "Uvarajan Deenathayalan"
A multifaceted and widely prevalent neurodegenerative disease, Parkinson's disease (PD) is typified by the loss of dopaminergic neurons in the midbrain. The discovery of novel treatment(s) that can reverse or halt the course of the disease progression along with identifying the most reliable biomarker(s) in PD remains the crucial concern. RhoA in its active state has been demonstrated to interact with three distinct domains located in the central coiled-coil region of ROCK.
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- Epilepsy affects about 70 million people globally, with roughly 30% of patients not responding to current antiepileptic drugs, underscoring the need for more effective treatments.
- The study investigates Necrostatin-1 (Nec-1), a selective RIPK1 inhibitor, for its potential anticonvulsant effects in zebrafish larvae with PTZ-induced seizures.
- Results showed that Nec-1 helped restore normal behavior, decreased inflammatory cytokine levels, and improved GABA receptor expression, indicating its potential as a new treatment approach for epilepsy.
Article Synopsis
- The study focuses on synthesizing non-toxic zinc oxide nanoparticles (ZnO NPs) from marine algae (Sargassum polycystum) due to concerns about their environmental impact and lack of regulation.* -
- Characterization methods showed that these nanoparticles are rod-shaped with an average diameter of about 100 nm and exhibit specific crystal properties.* -
- Toxicity tests using zebra fish larvae indicated that ZnO NPs caused developmental delays, increased deformities, oxidative stress, and changes in cellular activity, highlighting potential risks even with green synthesis methods.*