Publications by authors named "Uugantsetseg Munkhjargal"
Article Synopsis
- LCZ696 (sacubitril/valsartan) has cardioprotective effects and may improve endothelial function in diabetes, which needs further investigation.
- In a study on diabetic mice, both LCZ696 and valsartan lowered blood pressure and improved endothelium-dependent vascular relaxation, but only LCZ696 enhanced eNOS and Akt phosphorylation.
- The results indicate that LCZ696 improves diabetes-induced endothelial dysfunction by increasing atrial natriuretic peptide bioavailability, suggesting it may be more effective than valsartan for vascular protection in diabetes.
Aims: Pharmacological blockade of mineralocorticoid receptors (MRs) is a potential therapeutic approach to reduce cardiovascular complications since MRs play a crucial role in cardiovascular regulation. Recent studies suggest that MR antagonists affect several extrarenal tissues, including vessel function. We investigated the effect of a novel nonsteroidal selective MR blocker, esaxerenone, on diabetes-induced vascular dysfunction.
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