Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides.

Recent advances in the clinical development of oligonucleotide therapeutics, such as antisense oligonucleotides (ASOs) and small interfering RNAs, have attracted attention as promising therapeutic modalities for genetic and intractable diseases. These oligonucleotide therapeutics exert their efficacy by binding to target RNAs present within cells; however, the mechanisms underlying their cellular uptake, especially their passage through membranes, remain largely unclear. In the nematode, Caenorhabditis elegans, the multi-pass transmembrane protein, SID-1, is involved in the cellular uptake of double-stranded RNAs.

An autopsy case of constrictive pericarditis following open chest surgery with severe pulmonary hypertension treated as HFpEF.

Unlabelled: A 73-year-old man with a history of aortic arch replacement for chronic type B aortic dissective aneurysm was admitted for heart failure. He had normal left ventricular systolic function and had pulmonary hypertension with a pulmonary artery pressure of approximately 90 mmHg. He had been diagnosed with pneumoconiosis from his occupation and pulmonary hypertension due to heart failure with preserved ejection fraction (HFpEF) and respiratory disease.

Thoracoscopic and endoscopic cooperative surgery for esophageal gastrointestinal stromal tumor: a case report.

Background: Esophageal gastrointestinal stromal tumors (GISTs) are relatively rare, accounting for 2-5% of all GISTs. Typically, the treatment is surgery in nature. However, no standard procedure established for esophageal GISTs, and in many cases, subtotal esophagectomy or local resection via thoracoscopy or mediastinoscopy is performed.

Case report: Atypical lipomatous tumor of the thigh in a four-year-old girl.

Atypical lipomatous tumors (ALTs) are locally aggressive adipocytic malignancies that frequently occur in middle-aged adults. We report the rare case of an ALT of the thigh that occurred in a 4-year-old girl. Since the tumor was initially diagnosed as a lipoblastoma by incisional biopsy, marginal resection was performed.

Effective Oral Indicators With Medical and Dental Collaboration in Open Heart Surgery: A Representative Survey.

Purpose Postoperative infections pose an important problem for patients with cardiac disease. Moreover, oral health status is associated with the risk of longer hospital stays. Therefore, the oral health status of patients was assessed before open-heart surgery.

Performance evaluation of automated scoring for the descriptive similarity response task.

We examined whether a machine-learning-based automated scoring system can mimic the human similarity task performance. We trained a bidirectional encoder representations from transformer-model based on the semantic similarity test (SST), which presented participants with a word pair and asked them to write about how the two concepts were similar. In Experiment 1, based on the fivefold cross validation, we showed the model trained on the combination of the responses (N = 1600) and classification criteria (which is the rubric of the SST; N = 616) scored the correct labels with 83% accuracy.

Emotional characteristic analysis of human gait while real-time movie viewing.

Emotion recognition is useful in many applications such as preventing crime or improving customer satisfaction. Most of current methods are performed using facial features, which require close-up face information. Such information is difficult to capture with normal security cameras.

A test of indirect grounding of abstract concepts using multimodal distributional semantics.

How are abstract concepts grounded in perceptual experiences for shaping human conceptual knowledge? Recent studies on abstract concepts emphasizing the role of language have argued that abstract concepts are grounded indirectly in perceptual experiences and language (or words) functions as a bridge between abstract concepts and perceptual experiences. However, this "indirect grounding" view remains largely speculative and has hardly been supported directly by empirical evidence. In this paper, therefore, we test the indirect grounding view by means of multimodal distributional semantics, in which the meaning of a word (i.

Nelarabine-induced rhabdomyolysis in a patient with T-cell acute lymphoblastic leukemia: a case report.

Background: Nelarabine is an antineoplastic purine analog used for the treatment of refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL). The most prominent side effect of nelarabine are neurotoxicity and hematologic disorder, which are considered dose-limiting factors. Although clinical studies have reported myopathy due to nelarabine, actual detailed outcomes were not well-known initial approval.

Context-prosody interaction in sarcasm comprehension: A functional magnetic resonance imaging study.

During conversation, sarcasm is perceived as an incongruity between the context, content, and prosody of the utterance. We hypothesized that prosody modifies the context‒content incongruity effect. Thus, we conducted a functional magnetic resonance imaging study with an auditory sarcasm detection task in 22 healthy adult participants.

Analysis of the variable factors affecting changes in the blood concentration of cyclosporine before and after transfusion of red blood cell concentrate.

Background: The blood concentration of cyclosporine (CyA) is frequently elevated following the transfusion of red blood cell concentrate (RCC) to patients after allogeneic hematopoietic stem cell transplantation (HSCT). The aim of this retrospective study was to identify the variable factors affecting changes in the blood concentration of CyA before and after transfusion of RCC.

Methods: We enrolled 105 patients (age, 5-66 years) who received both CyA and transfusion after HSCT.

Exploring What Is Encoded in Distributional Word Vectors: A Neurobiologically Motivated Analysis.

The pervasive use of distributional semantic models or word embeddings for both cognitive modeling and practical application is because of their remarkable ability to represent the meanings of words. However, relatively little effort has been made to explore what types of information are encoded in distributional word vectors. Knowing the internal knowledge embedded in word vectors is important for cognitive modeling using distributional semantic models.

Study of pharmacist intervention in polypharmacy among older patients: Non-randomized, controlled trial.

Aim: We investigated the outcomes of interdisciplinary drug therapy interventions by pharmacists among older residents of special elderly nursing homes.

Methods: The study was designed as a non-randomized, parallel-group, controlled study. Four nursing homes were allocated in a 1:1 ratio to an intervention group (IG) or control group (CG).

Influence of Oral Anaerobic Bacteria on Hematopoietic Stem Cell Transplantation Patients: Oral Mucositis and General Condition.

Objective: Oral mucositis (OM) caused by infection facilitated by myelosuppression and immunosuppression can be controlled through oral care. We investigated changes in oral anaerobic bacterial flora during the onset of OM with hematopoietic stem cell transplantation (HSCT).

Methods: This study included 19 patients who underwent HSCT.

The role of the amygdala in incongruity resolution: the case of humor comprehension.

A dominant theory of humor comprehension suggests that people understand humor by first perceiving some incongruity in an expression and then resolving it. This is called "the incongruity-resolution theory." Experimental studies have investigated the neural basis of humor comprehension, and multiple neural substrates have been proposed; however, the specific substrate for incongruity resolution is still unknown.

The role of prosody and context in sarcasm comprehension: Behavioral and fMRI evidence.

A hearer's perception of an utterance as sarcastic depends on integration of the heard statement, the discourse context, and the prosody of the utterance, as well as evaluation of the incongruity among these aspects. The effect of prosody in sarcasm comprehension is evident in everyday conversation, but little is known about its underlying mechanism or neural substrates. To elucidate the neural underpinnings of sarcasm comprehension in the auditory modality, we conducted a functional MRI experiment with 21 adult participants.

A Complex Network Approach to Distributional Semantic Models.

A number of studies on network analysis have focused on language networks based on free word association, which reflects human lexical knowledge, and have demonstrated the small-world and scale-free properties in the word association network. Nevertheless, there have been very few attempts at applying network analysis to distributional semantic models, despite the fact that these models have been studied extensively as computational or cognitive models of human lexical knowledge. In this paper, we analyze three network properties, namely, small-world, scale-free, and hierarchical properties, of semantic networks created by distributional semantic models.

Discourse Goals Affect the Process and Product of Nominal Metaphor Production.

Although a large number of studies have addressed metaphor comprehension, only a few attempts have so far been made at exploring the process of metaphor production. Therefore, in this paper, we address the problem of how people generate nominal metaphors or identify an apt vehicle for a given topic of nominal metaphors. Specifically, we examine how the process and product of metaphor production differ between two discourse goals of metaphor, namely an explanatory purpose (e.

Adjective metaphors evoke negative meanings.

Previous metaphor studies have paid much attention to nominal metaphors and predicative metaphors, but little attention has been given to adjective metaphors. Although some studies have focused on adjective metaphors, they only examined differences in the acceptability of various types of adjective metaphors. This paper explores the cognitive effects evoked by adjective metaphors.

Hereditary spastic paraplegia protein spartin is an FK506-binding protein identified by mRNA display.

Here, we used mRNA display to search for proteins that bind to FK506, a potent immunosuppressant drug, and identified spartin, a hereditary spastic paraplegia protein, from a human brain cDNA library. We demonstrated that FK506 binds to the C-terminal region of spartin and thereby inhibits the interaction of spartin with TIP47, one of the lipid droplet-associated proteins. We further confirmed that FK506 inhibits localization of spartin and its binder, an E3 ubiquitin ligase AIP4, in lipid droplets and increases the protein level of ADRP (adipose differentiation-related protein), which is a regulator of lipid homeostasis.

Neural basis of impaired cognitive flexibility in patients with anorexia nervosa.

Background: Impaired cognitive flexibility in anorexia nervosa (AN) causes clinical problems and makes the disease hard to treat, but its neural basis has yet to be fully elucidated. The purpose of this study was to evaluate the brain activity of individuals with AN while performing a task requiring cognitive flexibility on the Wisconsin Card Sorting Test (WCST), which is one of the most frequently used neurocognitive measures of cognitive flexibility and problem-solving ability.

Methods: Participants were 15 female AN patients and 15 age- and intelligence quotient-matched healthy control women.

Formation of non-toxic Aβ fibrils by small heat shock protein under heat-stress conditions.

Small heat shock protein (sHsp) is a molecular chaperone with a conserved alpha-crystallin domain that can prevent protein aggregation. It has been shown that sHsps exist as oligomers (12-40 mer) and their dissociation into small dimers or oligomers is functionally important. Since several sHsps are upregulated and co-localized with amyloid-β (Aβ) in senile plaques of patients with Alzheimer's disease (AD), sHsps are thought to be involved in AD.

Computational exploration of metaphor comprehension processes using a semantic space model.

Recent metaphor research has revealed that metaphor comprehension involves both categorization and comparison processes. This finding has triggered the following central question: Which property determines the choice between these two processes for metaphor comprehension? Three competing views have been proposed to answer this question: the conventionality view (Bowdle & Gentner, 2005), aptness view (Glucksberg & Haught, 2006b), and interpretive diversity view (Utsumi, 2007); these views, respectively, argue that vehicle conventionality, metaphor aptness, and interpretive diversity determine the choice between the categorization and comparison processes. This article attempts to answer the question regarding which views are plausible by using cognitive modeling and computer simulation based on a semantic space model.

[Study of cerebellar infarction with isolated vertigo].

Isolated vertigo is generally attributed to labyrinthine disease, but may also signal otherwise asymptomatic cerebellar infarction. Of 309 subjects admitted between April 2004 and March 2009 for the single symptom of acute vertigo initially thought to be labyrinthine, four were found to have cerebellar infarction of the posterior inferior cerebellar artery area (PICA). All were over 60 years old and had risk factors including hypertension, diabetes mellitus, arrhythmia, and/or hyperlipidemia.