Publications by authors named "Utsow Saha"

Vasculitides represent a range of disorders marked by inflammation of blood vessels, often posing significant diagnostic challenges due to their diverse clinical presentations and involvement of multiple organ systems. We present the case of a 26-year-old woman who arrived with hemoptysis and a background of exertional dyspnea, chest pain, and occasional visual disturbances. Initial investigations showed elevated perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCAs) and myeloperoxidase antibodies (MPOs), indicative of microscopic polyangiitis (MPA).

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Every year, pulmonary embolism (PE) causes about 100,000 fatalities in the United States. Acute PE is a prevalent and occasionally fatal kind of venous thromboembolism (VTE). PE can appear in a variety of ways and is frequently nonspecific in its clinical presentation, making its diagnosis challenging.

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A patient's demographics often guide healthcare providers toward clues to a diagnosis. A recent travel history becomes an essential piece of the puzzle when there is a high suspicion of an infectious cause. When a patient walks into the hospital after having traveled to or from a resource-poor country with systemic afflictions, a physician's mind quickly jumps to infectious causes, and in most circumstances, it proves to be correct.

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Background: Gastroparesis is a condition that affects the motility of the gastrointestinal (GI) tract, causing a delay in the emptying process and leading to nausea, vomiting, bloating, and upper abdominal pain. Motility treatment along with symptom management can be done using antiemetics or prokinetics. This study highlights the diagnostic and therapeutic challenges of gastroparesis and suggests a potential link between facial trauma and symptom remission, indicating the need for further investigation.

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Patients with venous thromboembolism (VTE) frequently employ inferior vena cava (IVC) filters to keep them from getting pulmonary embolisms. Even though they are usually thought to be safe, there can be complications during or after their placement. IVC filter perforation into adjacent structures, such as the duodenum, is an uncommon but potentially serious complication.

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Background: Cochlear implants (CIs) restore hearing to deafened patients. The foreign body response (FBR) following cochlear implantation (post-CI) comprises an infiltration of macrophages, other immune and non-immune cells, and fibrosis into the scala tympani, a space that is normally devoid of cells. This FBR is associated with negative effects on CI outcomes including increased electrode impedances and loss of residual acoustic hearing.

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Article Synopsis
  • * Hepatic abscesses and gallbladder perforations can occur as complications, with the former indicating direct liver tissue involvement and the latter resulting from increased pressure and necrosis in the gallbladder wall.
  • * A clinical case of a 69-year-old male highlighted the challenges of diagnosis, as he presented with impending gallbladder perforation and was ultimately found to have advanced metastatic gallbladder cancer despite initial misdiagnosis of hepatic abscesses.
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Article Synopsis
  • Cochlear implants (CIs) can help restore hearing in deaf individuals but often lead to negative outcomes due to the foreign body response (FBR), which includes immune cell infiltration and fibrosis.
  • This study examines the effects of a specific drug, PLX-5622, that depletes macrophages to see if it can improve this tissue response and enhance neural health post-implantation.
  • Researchers used a mouse model to measure the impact of the treatment on cochlear health and the fibrosis response after cochlear implantation, analyzing tissue samples at several time points following the procedure.
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Since the last century, methicillin-resistant (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growing antimicrobial resistance due to their misuse and overuse, which has led the world to be exhausted of its effective antibiotic resources. In this review article, we sought to figure out the most efficacious antimicrobial agents to treat MRSA-related bloodstream infections.

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Among many clinical symptoms, hiccups are an infrequent presentation of hyponatremia. Hyponatremia indicates a serum sodium level of less than 135 mmol/l, the most common reported electrolyte abnormality. Cerebral salt wasting syndrome is a less common cause of hyponatremia, which can arise from a spectrum of brain pathology.

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