Publications by authors named "Utkarsh Parwal"
Article Synopsis
- The inferior mesenteric artery (IMA) and vein (IMV) are crucial for blood supply and drainage of the distal colon and rectum, but often overlooked in imaging due to their small size.
- The article discusses normal and abnormal appearances of these vessels, covering various vascular issues such as aneurysms, stenosis, and potential diagnostic clues that radiologists should be aware of.
- The authors emphasize the importance of recognizing the IMA and IMV in the context of gastrointestinal health and provide case examples to illustrate their relevance in diagnosing vascular abnormalities and collateral circulation.
DNA damage, induced by either chemical carcinogens or environmental pollutants, plays an important role in the initiation of colorectal cancer. DNA repair processes, however, are involved in both protecting against cancer formation, and also contributing to cancer development, by ensuring genomic integrity and promoting the efficient DNA repair in tumor cells, respectively. Although DNA repair pathways have been well exploited in the treatment of breast and ovarian cancers, the role of DNA repair processes and their therapeutic efficacy in colorectal cancer is yet to be appreciably explored.
View Article and Find Full Text PDFRAD51-associated protein 1 (RAD51AP1) plays an integral role in homologous recombination by activating RAD51 recombinase. Homologous recombination is essential for preserving genome integrity and RAD51AP1 is critical for D-loop formation, a key step in homologous recombination. Although RAD51AP1 is involved in maintaining genomic stability, recent studies have shown that RAD51AP1 expression is significantly upregulated in human cancers.
View Article and Find Full Text PDF