Sexual desire after olfactory loss: Quantitative and qualitative reports of patients with smell disorders.

Olfaction moderates human sexual experiences and smell disorder patients sometimes spontaneously complain about impairments in their sexual life. The aim of the present study was to systematically investigate the impact of olfactory dysfunction on sexual desire. We compared a sample of n = 100 (n = 52 women; aged 23-51 years, M = 40.

Assessment of Chemosensory Function Using "Sniffin' Sticks", Taste Strips, Taste Sprays, and Retronasal Olfactory Tests.

Background: Approximately 5% of the general population is affected by functional anosmia. An additional 15% exhibit decreased olfactory function. Many of these individuals ask ENT-doctors or neurologists for help.

Effect of training frequency on the learning curve on the da Vinci Skills Simulator.

Background: The purpose of this study was to evaluate the effect of training on the performance outcome with the da Vinci Skills Simulator.

Methods: Forty novices were enrolled in a prospective training curriculum. Participants were separated into 2 groups.

Clinical Outcome and Quality of Life After a Multimodal Therapy Approach to Ear Keloids.

Importance: Keloids are fibroproliferative scars that can cause a huge psychological burden and severe problems for patients, such as depression. Many treatment options exist; however, recurrence rates, especially with monotherapy, remain high.

Objective: To investigate the recurrence rate and changes in quality of life after multimodal therapy.

Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis.

The composition of tumor-targeted T cell infiltrates is a major prognostic factor in colorectal cancer (CRC) outcome; however, the functional role of these populations in prolonging patient survival remains unclear. Here, we evaluated 190 patients with CRC for the presence of functionally active tumor-infiltrating lymphocytes (TILs), the tumor specificity of these TILs, and the correlation between patient TILs and long-term survival. Using intracytoplasmic cytokine staining in conjunction with HLA multimers loaded with tumor peptide and antigen-specific cytokine secretion assays, we determined that TNF-α expression delineates a population of tumor antigen-specific (TA-specific) cytotoxic T lymphocytes (CTLs) present within tumors from patients with CRC.

Interaction of a CD44+ head and neck squamous cell carcinoma cell line with a stromal cell-derived factor-1-expressing supportive niche: An model.

The cancer stem cell (CSC) theory implies that CSCs are surrounded by supportive stromal cells, which are known as the CSC niche. Stromal cell-derived factor-1 (SDF-1) shows a multitude of functional effects in head and neck squamous cell carcinoma (HNSCC) cells, including migration and polarization. Therefore, the SDF-1-CXCR4 axis may be involved in the pathophysiology of the progression, recurrence and metastasis of malignant diseases of the head and neck.