Publications by authors named "Uta Wieland"
Proc Natl Acad Sci U S A
April 2012
Article Synopsis
- Mutations in Drosophila merry-go-round (mgr) lead to abnormal cell division and disruption of spindles, but the specific protein it encodes was previously unknown.
- Research reveals that mgr encodes a Prefoldin protein similar to human von Hippel Lindau binding-protein 1, crucial for maintaining microtubule stability in cells.
- Mgr and von Hippel Lindau protein (Vhl) work together to manage tubulin levels, with Vhl helping to degrade misfolded tubulin when Prefoldin is not functioning properly, highlighting their roles in regulating tubulin stability.
