Publications by authors named "Usharani Brammacharry"
Article Synopsis
- Fluoroquinolone resistance poses a significant challenge in treating Multidrug-Resistant Tuberculosis (MDR-TB), with notable resistance rates of 33% in MDR-TB and 16.5% in Rifampicin-Resistant TB.
- The most common mutation linked to fluoroquinolone resistance was found in the gyrA gene, specifically D94G, and there was a notable prevalence of pre-XDR-TB and Extensively Drug-Resistant TB among MDR-TB isolates.
- The study emphasizes the urgent need for rapid diagnosis of fluoroquinolone resistance to improve treatment outcomes and control resistance spread in high-prevalence areas.
Background/objectives: Mycobacterium tuberculosis, the causative agent of tuberculosis has developed resistance to most of the available antimicrobials. Therefore research on the detection of new antimicrobials against Mycobacterium tuberculosis is needed urgently. Essential oils extracted from plants have been shown to have anti-Mycobacterium tuberculosis effect in in-vitro experiments.
View Article and Find Full Text PDFBackground/objectives: Mycobacterium tuberculosis, the causative agent of tuberculosis has developed resistance to most of the available antimicrobials. Consequently, it is difficult to cure all the patients with tuberculosis and in future, the incidence of tuberculosis by drug resistant M. tuberculosis is likely to increase, worldwide.
View Article and Find Full Text PDFIndia accounts for about one-fourth of the global burden of MDR-TB. This study aims to assess the prevalence and factors associated with tuberculosis drug resistance among patients from South India. MTBDRplus assay and MGIT liquid culture performed on 20,245 sputum specimens obtained from presumptive MDR-TB cases during a six-year period from 2013 to 2018 were analyzed retrospectively.
View Article and Find Full Text PDFPrevalence of mutations in genes associated with isoniazid resistance in Mycobacterium tuberculosis isolates from re-treated smear-positive pulmonary tuberculosis patients: A meta-analysis.
J Glob Antimicrob Resist
September 2018
Objectives: The prevalence of isoniazid (INH) monoresistance is high in India. In this study, molecular epidemiological characteristics associated with INH resistance mutations in Mycobacterium tuberculosis in codon katG315 and in the promoter region of the inhA gene were investigated.
Methods: Sputum specimens of smear-positive tuberculosis (TB) patients were subjected to GenoType MTBDRplus assay to identify katG and inhA mutations in M.
Rapid and sensitive detection of Mycobacterium tuberculosis from patient samples is vital for clinical diagnosis and treatment. The emergence of M. tuberculosis strains with either no copies or only a single copy of IS6110 in Asian countries makes the standard PCR based diagnosis of M.
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