Penicillin Acylase-Catalyzed Effective and Stereoselective Acylation of 1-phenylethylamine in Aqueous Medium using Non-Activated Acyl Donor.

Until recently, the biocatalytic preparation of enantiomerically pure amines was based on stereoselective acyl transfer in an organic medium using activated acyl donors. The possibility of performing an effective and enantioselective enzymatic acylation of amines in an aqueous medium without using activated acyl donors was demonstrated for the first time as the example of direct condensation of phenylacetic acid and racemic 1-phenylethylamine. Direct condensation of the acid and the amine took place at mild reaction conditions with a high initial rate (3.

[Acute psychogenic disorders in lepers].

The authors carried out clinical follow-up and psychological examinations of 40 patients suffering from leprosy and treated at the Astrakhan Institute for Leprosy Research. Under study there were acute psychogenic reactions arising in the patients on diagnosing the disease and putting them to the leprosery. Clinical variants of adequate situational reactions (21 patients) and anomalous neurotic and psychopathic ones (19 patients) are described.

[Types of personality reactions in children and adolescents with hysterical disorders].

Results of clinical and catamnestic examinations of 108 children aged 5 to 10 years with diagnoses of hysterical reactions, hysterical states, and hysterical type of development are presented. An analysis of anamnestic data revealed factors of increased risk that contributed to the dysharmonic development of the individuals suffering from hysterical neurosis. Forms of personal hysterical responses, such as, hysterical, hysteroasthenic, hystero-explosive, and hystero-phobic ones, are classified.

[Clinicobiochemical parallels in borderline neuropsychic disorders].

Under examination there were 173 patients with borderline neuropsychic disorders of the neurotic and neurosis-like genesis. In the course of the treatment the levels of acetylcholine and catecholamines were determined. It has been shown that in borderline neuropsychic disorders there are statistically significant differences in the levels of those neuromediators, these differences being characteristic for the neurotic and neurosis-like disorders.

[Semeiotics of the mental status of children with respect to circadian and age dynamics during early postnatal ontogeny. Mental status of "autarchy"].

In studying early ontogenesis of infant personality it was possible for the first time to determine the mental state of "autarkeia". The state of autarkeia appears at the age of 3-4 weeks in a normal infant at the end of the biorhythm period of "Satiated wakefulness" and reflects a state of comfort without any necessities. The state of autarkeia at the end of the first month of life is considered as an egg stage in the development of social and subjective contacts, when the respective necessities are not yet formed, while the conditions are already mature.

[Clinical picture and activity of nervous system mediators during chronic modeling of certain factors involved in space flight].

Results of examining the functions of the nervous system and the activity of blood neuromediators after a long-time (182 days) antiorthostatic hypokinesia are presented. It has been shown that along with polymorphic clinical signs on the part of the nervous system (hemodynamic disturbances, asthenoneurotic manifestations, neuromuscular, metabolic, trophic, and vegetovascular disturbances, signs of insufficient training of the cardiovascular system, stato-kinetic and pain phenomena) undulating changes of the neuromediator activity reflecting the course of compensation and adaptation processes in the conditions of long-time hypokinesia are observed.

[Pupillary reactions in neurotic disorders].

For the differentiation of neurotic disorders, the indices of pupilary reactions and hippus were studied. The study was performed with the aid of a pupillograph. A comparison of the pupillographic data in patients with borderline neurotic disorders of the 3 main groups (asthenic, obsessive-phobic and hysterical), demonstrated statistically significant differences in the control group and within the group with different forms of neurotic disorders.

[State of neuromediator systems during formation of the psychoorganic syndrome caused by hypertension].

The state of the neuromediator systems in the formation of a psychosomatic development was studied in 66 patients with different stages of the hypertensive disease. It was demonstrated that the phases of the psychoorganic syndrome frequently correlated with the stages of hypertensive disease and with the qualitative and quantitative transformation of neuromediators in the peripheral blood and that the reactions of the neuromediator systems to dosaged stress may be used to evaluate the stage of the psychoorganic syndrome.