Publications by authors named "Urvi M Patel"
Article Synopsis
- Scientists found a molecule called NR4A1 that helps cancer cells survive in a protective environment.
- They created a special drug called NR-V04 that can remove NR4A1 from cells quickly and safely, making it easier for the body's immune system to fight cancer.
- Tests showed that NR-V04 not only shrinks tumors but also helps important immune cells become stronger, making it a promising treatment for cancers like melanoma.
An effective cancer therapy requires both killing cancer cells and targeting tumor-promoting pathways or cell populations within the tumor microenvironment (TME). We purposely search for molecules that are critical for multiple tumor-promoting cell types and identified nuclear receptor subfamily 4 group A member 1 (NR4A1) as one such molecule. NR4A1 has been shown to promote the aggressiveness of cancer cells and maintain the immune suppressive TME.
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