Publications by authors named "Urvashi Somani"
Article Synopsis
- Trichomonas vaginalis (Tv) is a protozoan parasite that causes trichomoniasis, the most prevalent non-viral sexually transmitted infection globally, but current treatment options are limited and facing resistance issues.
- Researchers are targeting the proteasome, a key enzyme complex in eukaryotes, to develop new treatments by isolating the enzyme and identifying specific inhibitors for its three catalytic subunits (β1, β2, β5).
- By creating specialized substrates for each subunit and screening a library of inhibitors, the study found that targeting the Tv β5 subunit is particularly effective in killing the parasite, which may lead to improved drug development strategies against trichomoniasis.
The protozoan parasite, (Tv) causes trichomoniasis, the most common, non-viral, sexually transmitted infection in the world. Only two closely related drugs are approved for its treatment. The accelerating emergence of resistance to these drugs and lack of alternative treatment options poses an increasing threat to public health.
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